Detailed information of TA system TA028549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 570110..570672
• Replicon: chromosome
• Accession: NC_019748
• Organism: Stanieria cyanosphaera PCC 7437

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K9XNC6
• Locus tag: STA7437_RS02405
• Protein ID: WP_015191773.1
• Coordinates: 570110..570439 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K9XPY8
• Locus tag: STA7437_RS02410
• Protein ID: WP_015191774.1
• Coordinates: 570436..570672 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STA7437_RS26065	565279..565779	-	501	Protein_483	PAS domain-containing protein	-
STA7437_RS26070	566044..568746	-	2703	Protein_484	response regulator	-
STA7437_RS02400	569363..570067	+	705	WP_150109027.1	hypothetical protein	-
STA7437_RS02405	570110..570439	-	330	WP_015191773.1	type II toxin-antitoxin system VapC family toxin	Toxin
STA7437_RS02410	570436..570672	-	237	WP_015191774.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
STA7437_RS02415	570934..573825	+	2892	WP_015191775.1	hypothetical protein	-
STA7437_RS02420	573918..574649	-	732	WP_015191776.1	polysaccharide deacetylase family protein	-
STA7437_RS02425	574926..575642	+	717	WP_150109028.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-99)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 11900.89 Da
• Isoelectric Point: 8.9166

>T28549 WP_015191773.1 NC_019748:c570439-570110 [Stanieria cyanosphaera PCC 7437]
MKFLLDTNICIYIIKQKPSAVLKKFKAYNVGDIGISSITVAELEFGVQKSQSPGKNQQALAQFLLPLTVVDFDLAATTMY
GIIRSKLEKQETPIGSLDTLTFVSGNSLS

Nucleotide

• Length: 330 bp

>T28549 NC_019748:c570439-570110 [Stanieria cyanosphaera PCC 7437]
ATGAAATTTTTACTAGACACTAATATTTGCATTTATATCATCAAACAGAAGCCTTCAGCAGTATTAAAGAAATTTAAAGC
TTACAATGTCGGAGATATAGGTATATCTTCAATTACTGTTGCTGAACTTGAATTTGGTGTCCAGAAGAGTCAATCTCCAG
GAAAAAATCAACAAGCATTAGCACAATTTTTACTGCCTTTAACAGTAGTAGATTTCGATCTTGCTGCTACTACTATGTAT
GGCATAATTCGCTCGAAACTAGAAAAACAAGAAACTCCAATCGGCTCTTTAGATACTTTAACTTTTGTGAGCGGGAATTC
TCTCTCCTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9242.42 Da
• Isoelectric Point: 8.4812

>AT28549 WP_015191774.1 NC_019748:c570672-570436 [Stanieria cyanosphaera PCC 7437]
VETAKLFQNGKSQAVRLPKQYRFPGYKVLIKRMGNAVVLLPYQNSWETLFESLEQFSDDFMDGNRQQPRQQERENAFE

Nucleotide

• Length: 237 bp

>AT28549 NC_019748:c570672-570436 [Stanieria cyanosphaera PCC 7437]
GTGGAAACAGCTAAACTTTTTCAAAATGGTAAAAGTCAGGCGGTTCGGCTACCTAAGCAATATCGTTTTCCAGGATATAA
AGTTCTAATTAAGCGTATGGGTAATGCAGTTGTGCTTTTACCTTATCAAAATTCTTGGGAAACTTTATTTGAAAGTTTAG
AACAATTTTCCGATGATTTTATGGATGGCAACCGTCAACAACCTAGACAACAAGAGCGAGAAAATGCTTTTGAATGA

Structures

Toxin

• AlphaFold DB: K9XNC6

Antitoxin

• AlphaFold DB: K9XPY8