285481

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 252058..253790 Replicon chromosome
Accession NZ_LN614827
Organism Legionella fallonii LLAP-10

Toxin (Protein)


Gene name pmenT Uniprot ID A0A098FZP2
Locus tag LFA_RS00985 Protein ID WP_045094536.1
Coordinates 252058..252699 (+) Length 214 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID A0A098G142
Locus tag LFA_RS00990 Protein ID WP_045094537.1
Coordinates 252699..253790 (+) Length 364 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFA_RS00955 247429..248373 + 945 WP_045094530.1 SDR family NAD(P)-dependent oxidoreductase -
LFA_RS00960 248404..248703 + 300 WP_045094531.1 hypothetical protein -
LFA_RS00965 248977..249321 + 345 WP_157010239.1 hypothetical protein -
LFA_RS00970 249627..250694 + 1068 WP_045094533.1 serine protease -
LFA_RS00975 250882..251310 + 429 WP_045094534.1 hypothetical protein -
LFA_RS00980 251382..251936 + 555 WP_045094535.1 hypothetical protein -
LFA_RS00985 252058..252699 + 642 WP_045094536.1 DUF4433 domain-containing protein Toxin
LFA_RS00990 252699..253790 + 1092 WP_045094537.1 macro domain-containing protein Antitoxin
LFA_RS01000 254578..256197 - 1620 WP_045094539.1 Fic family protein -
LFA_RS01005 256425..257084 - 660 WP_045094540.1 hypothetical protein -
LFA_RS01010 257100..257915 - 816 WP_045094541.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-213)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 214 a.a.        Molecular weight: 25004.52 Da        Isoelectric Point: 6.6909

>T285481 WP_045094536.1 NZ_LN614827:252058-252699 [Legionella fallonii LLAP-10]
MTYSHLNAEKALIWRITHKDNISGILDNGLYCANSPIQIPCYTPIGNIELIGKRKNRIVSLHPGGTLSDYIPFYFTHFSP
MMYNIHTGRGVKQYHNSELLILVSSLRLVEENNLEFLFTDRHAYLQRANYYNNLDSLSEIDWLSLQQRDFRLNPEDPEKF
DRYQAEALIYNHLPINSLKGIVCYTDELKLQIENEIDMRNLSLTVVTKPRWYF

Download         Length: 642 bp

Antitoxin


Download         Length: 364 a.a.        Molecular weight: 41459.21 Da        Isoelectric Point: 7.9457

>AT285481 WP_045094537.1 NZ_LN614827:252699-253790 [Legionella fallonii LLAP-10]
MITYKQGNLLTANAEALVNTVNTLGVMGKGIALMFKEKFPDNMKSYKAACHANQVQTGKMFITQCETAQPRWIINFPTKQ
HWRNPSKMEWIVSGLKDLREFIVTNDIKSIAIPPLGAGNGGLLWQAVRKQIEAILGDLEDVDIQLYEPTAEYQNVSKQTR
LIKLTPARALIIELVRRYWILGVECSLLEIQKLAWFLERSIKLFSPELSLKFKFKPHYYGPYADNLRYLLGALDGNYLCS
EKRINDAAPLDVIWLNDSYKEPLQAYLESKEMEPYAKALEFTSKLIDGFESPFEMELLATVDWLIEVDHCSPDVESLLTG
LKNWKQSTAVKRKMRLFDAHAISIALKRLETIKPDRAFLSTSC

Download         Length: 1092 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A098FZP2

Antitoxin

Source ID Structure
AlphaFold DB A0A098G142

References