Detailed information of TA system TA028546

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Txe-RelB
• Location: 3471760..3472345
• Replicon: chromosome
• Accession: NC_019745
• Organism: Gloeocapsa sp. PCC 7428

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K9XHS1
• Locus tag: GLO7428_RS26790
• Protein ID: WP_015189466.1
• Coordinates: 3472073..3472345 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: K9XG49
• Locus tag: GLO7428_RS15250
• Protein ID: WP_015189465.1
• Coordinates: 3471760..3472062 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLO7428_RS27915	3466819..3466992	-	174	WP_015189460.1	hypothetical protein	-
GLO7428_RS15230	3467182..3467889	-	708	WP_015189461.1	Crp/Fnr family transcriptional regulator	-
GLO7428_RS15235	3468617..3470209	+	1593	WP_015189462.1	M48 family metalloprotease	-
GLO7428_RS15240	3470307..3471104	+	798	WP_015189463.1	COP23 domain-containing protein	-
GLO7428_RS15245	3471154..3471651	+	498	WP_015189464.1	DUF427 domain-containing protein	-
GLO7428_RS15250	3471760..3472062	+	303	WP_015189465.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GLO7428_RS26790	3472073..3472345	+	273	WP_015189466.1	Txe/YoeB family addiction module toxin	Toxin
GLO7428_RS15255	3472493..3473323	+	831	WP_015189467.1	4-hydroxy-tetrahydrodipicolinate reductase	-
GLO7428_RS15260	3473361..3474077	+	717	WP_015189468.1	hypothetical protein	-
GLO7428_RS15265	3474089..3474895	-	807	WP_015189469.1	TPM domain-containing protein	-
GLO7428_RS15270	3475164..3475766	-	603	WP_015189470.1	rhomboid family intramembrane serine protease	-
GLO7428_RS28550	3476133..3476492	-	360	Protein_3103	DUF948 domain-containing protein	-
GLO7428_RS15280	3476507..3476857	-	351	WP_015189472.1	YtxH domain-containing protein	-
GLO7428_RS15285	3476979..3477326	-	348	WP_015189473.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (11-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-69)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 11111.65 Da
• Isoelectric Point: 8.4500

>T28546 WP_015189466.1 NC_019745:3472073-3472345 [Gloeocapsa sp. PCC 7428]
IPPSVVHFPDFSPQFKEDLGWWYKTEPRKVDKIFDLVTDTMKHPFEGIGKPEKLKYIDSDTWSRRIDWEHRLIYRVRQDR
VDFLQARYHY

Nucleotide

• Length: 273 bp

>T28546 NC_019745:3472073-3472345 [Gloeocapsa sp. PCC 7428]
ATACCACCATCAGTAGTACACTTTCCTGACTTTAGTCCTCAATTCAAAGAAGATTTAGGTTGGTGGTACAAAACTGAACC
TCGCAAAGTAGACAAAATTTTTGACTTAGTTACAGACACAATGAAGCATCCCTTTGAGGGGATAGGTAAGCCTGAAAAAC
TTAAGTACATAGATTCTGATACTTGGTCGCGCCGTATAGACTGGGAGCATCGACTCATCTATAGAGTCAGACAAGACCGA
GTAGACTTTTTGCAAGCGCGTTATCACTATTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11164.56 Da
• Isoelectric Point: 4.7473

>AT28546 WP_015189465.1 NC_019745:3471760-3472062 [Gloeocapsa sp. PCC 7428]
MQTTYTKARENLASLLDKVVDDREIVAIERRHKPNVALVAEDELASLQQTAYLLRSPKNAARLLSALEWSQSRDEKNLES
VSVDEAIAALKQEIGGEEKS

Nucleotide

• Length: 303 bp

>AT28546 NC_019745:3471760-3472062 [Gloeocapsa sp. PCC 7428]
ATGCAGACTACATACACGAAAGCTCGTGAAAACTTAGCTTCTCTTTTAGATAAAGTTGTCGATGACCGAGAAATTGTTGC
GATCGAGCGTCGTCATAAGCCAAACGTAGCGCTAGTTGCAGAAGATGAACTCGCAAGTCTTCAACAGACAGCTTACCTCC
TGAGAAGCCCTAAAAATGCCGCACGTCTTTTGAGTGCTTTAGAGTGGTCACAATCAAGGGATGAGAAAAATTTAGAGTCA
GTCTCCGTGGATGAAGCGATCGCTGCATTAAAGCAGGAGATAGGAGGCGAAGAAAAAAGTTGA

Structures

Toxin

• AlphaFold DB: K9XHS1

Antitoxin

• AlphaFold DB: K9XG49