Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 909278..909807 Replicon chromosome
Accession NZ_LN554884
Organism Staphylococcus xylosus strain C2a

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4NYG1
Locus tag SXYL_RS04210 Protein ID WP_047172098.1
Coordinates 909445..909807 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1D4YKY9
Locus tag SXYL_RS04205 Protein ID WP_017722121.1
Coordinates 909278..909448 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SXYL_RS04180 905055..905534 + 480 WP_047172094.1 PH domain-containing protein -
SXYL_RS04185 905527..907035 + 1509 WP_047172095.1 PH domain-containing protein -
SXYL_RS04190 907022..907513 + 492 WP_047172096.1 PH domain-containing protein -
SXYL_RS04195 907575..907928 + 354 WP_042362337.1 holo-ACP synthase -
SXYL_RS04200 908042..909190 + 1149 WP_047172097.1 alanine racemase -
SXYL_RS04205 909278..909448 + 171 WP_017722121.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
SXYL_RS04210 909445..909807 + 363 WP_047172098.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SXYL_RS04215 910156..911157 + 1002 WP_047172099.1 PP2C family protein-serine/threonine phosphatase -
SXYL_RS04220 911237..911563 + 327 WP_029377954.1 anti-sigma factor antagonist -
SXYL_RS04225 911565..912047 + 483 WP_029377953.1 anti-sigma B factor RsbW -
SXYL_RS04230 912022..912792 + 771 WP_047172100.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13551.81 Da        Isoelectric Point: 10.3173

>T285458 WP_047172098.1 NZ_LN554884:909445-909807 [Staphylococcus xylosus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSEKKMKEVNIAIDISLGLHNIRNHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6305.92 Da        Isoelectric Point: 4.0121

>AT285458 WP_017722121.1 NZ_LN554884:909278-909448 [Staphylococcus xylosus]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4NYG1

Antitoxin

Source ID Structure
AlphaFold DB A0A1D4YKY9

References