Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4476431..4477245 Replicon chromosome
Accession NZ_LM995446
Organism Escherichia coli strain K-12 substr. RV308

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag ECRV308_RS22110 Protein ID WP_001054376.1
Coordinates 4476988..4477245 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag ECRV308_RS22105 Protein ID WP_001309181.1
Coordinates 4476431..4476976 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECRV308_RS22085 4472122..4473435 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
ECRV308_RS22090 4473447..4473725 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
ECRV308_RS22095 4473722..4474843 - 1122 WP_000010829.1 M42 family metallopeptidase -
ECRV308_RS25765 4475088..4475204 - 117 Protein_4181 VOC family protein -
ECRV308_RS25095 4475242..4475460 - 219 Protein_4182 hypothetical protein -
ECRV308_RS22100 4475629..4476375 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
ECRV308_RS22105 4476431..4476976 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
ECRV308_RS22110 4476988..4477245 - 258 WP_001054376.1 hypothetical protein Toxin
ECRV308_RS25555 4477622..4477867 - 246 Protein_4186 GNAT family N-acetyltransferase -
ECRV308_RS22125 4477983..4479223 + 1241 Protein_4187 helicase YjhR -
ECRV308_RS22130 4479806..4480786 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ECRV308_RS22135 4480851..4481957 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimB / fimE 4473722..4486601 12879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T285452 WP_001054376.1 NZ_LM995446:c4477245-4476988 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT285452 WP_001309181.1 NZ_LM995446:c4476976-4476431 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References