Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4391639..4392234 Replicon chromosome
Accession NZ_LM995446
Organism Escherichia coli strain K-12 substr. RV308

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag ECRV308_RS21675 Protein ID WP_000239577.1
Coordinates 4391884..4392234 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag ECRV308_RS21670 Protein ID WP_001223208.1
Coordinates 4391639..4391890 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECRV308_RS21660 4387304..4391083 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
ECRV308_RS21665 4391086..4391427 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
ECRV308_RS21670 4391639..4391890 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
ECRV308_RS21675 4391884..4392234 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
ECRV308_RS21680 4392314..4392844 - 531 WP_000055075.1 inorganic diphosphatase -
ECRV308_RS21685 4393154..4394110 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
ECRV308_RS21690 4394250..4395752 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
ECRV308_RS21695 4395766..4396788 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T285451 WP_000239577.1 NZ_LM995446:4391884-4392234 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT285451 WP_001223208.1 NZ_LM995446:4391639-4391890 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References