Detailed information of TA system TA028545

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-AbrB
• Location: 1328503..1329070
• Replicon: chromosome
• Accession: NC_019745
• Organism: Gloeocapsa sp. PCC 7428

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: GLO7428_RS05905
• Protein ID: WP_041918932.1
• Coordinates: 1328503..1328844 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: K9XCG3
• Locus tag: GLO7428_RS05910
• Protein ID: WP_015187655.1
• Coordinates: 1328831..1329070 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLO7428_RS05885	1324295..1326400	-	2106	WP_015187650.1	M48 family metalloprotease	-
GLO7428_RS05890	1326438..1326806	+	369	WP_015187651.1	VOC family protein	-
GLO7428_RS05895	1326962..1327258	-	297	WP_015187652.1	hypothetical protein	-
GLO7428_RS05900	1327283..1328389	-	1107	WP_015187653.1	magnesium chelatase ATPase subunit I	-
GLO7428_RS05905	1328503..1328844	-	342	WP_041918932.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
GLO7428_RS05910	1328831..1329070	-	240	WP_015187655.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
GLO7428_RS05915	1329136..1330647	-	1512	WP_015187656.1	FAD-dependent oxidoreductase	-
GLO7428_RS05920	1330914..1331348	+	435	WP_041918933.1	ferredoxin	-
GLO7428_RS05925	1331650..1332297	+	648	WP_015187658.1	response regulator transcription factor	-
GLO7428_RS05930	1332494..1332778	-	285	WP_015187659.1	NIL domain-containing protein	-
GLO7428_RS05935	1332788..1333660	-	873	WP_015187660.1	sulfate ABC transporter permease subunit CysW	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-110)

Antitoxin

• PrlF antitoxin (9-49)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12256.42 Da
• Isoelectric Point: 8.6595

>T28545 WP_041918932.1 NC_019745:c1328844-1328503 [Gloeocapsa sp. PCC 7428]
IVTYSQFDVVVVPFPFTDISATKRRPALVLSDEIFNTPSHRSVMAMITTASHSPWVLDVAIADLASTGLKAASVVRMKLF
TLDDSIVVKQIGILAQTDKLAVQKALQLLFAIA

Nucleotide

• Length: 342 bp

>T28545 NC_019745:c1328844-1328503 [Gloeocapsa sp. PCC 7428]
ATAGTGACCTATAGCCAGTTCGATGTTGTCGTCGTACCGTTTCCCTTTACTGATATTTCCGCGACAAAAAGACGTCCAGC
ACTTGTGTTAAGTGATGAAATTTTCAATACTCCTTCCCATAGAAGCGTAATGGCAATGATTACGACCGCAAGTCATTCTC
CATGGGTACTTGATGTTGCAATCGCTGACTTGGCAAGTACTGGACTTAAAGCAGCTTCTGTAGTAAGGATGAAGTTGTTT
ACCCTAGATGACTCAATAGTTGTAAAACAAATCGGTATTTTGGCTCAAACAGATAAATTAGCAGTTCAAAAAGCACTGCA
ACTACTTTTTGCGATCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8873.07 Da
• Isoelectric Point: 4.5702

>AT28545 WP_015187655.1 NC_019745:c1329070-1328831 [Gloeocapsa sp. PCC 7428]
MARRKSLVSRVTKKYQATIPQDVRKVLEIAQGDCVAFEIESGQVILKKAPSLDWNYLNAVAETLGEWESVADEEAYSDL

Nucleotide

• Length: 240 bp

>AT28545 NC_019745:c1329070-1328831 [Gloeocapsa sp. PCC 7428]
ATGGCTAGACGAAAATCACTCGTGTCTAGAGTGACAAAGAAATACCAAGCAACGATTCCTCAAGATGTCAGAAAAGTACT
GGAAATTGCGCAAGGTGATTGTGTAGCGTTTGAAATTGAGTCAGGACAAGTGATATTAAAAAAAGCGCCATCGCTTGATT
GGAATTATCTGAATGCTGTAGCAGAAACTCTAGGCGAATGGGAATCAGTTGCAGACGAGGAAGCCTATAGTGACCTATAG

Structures

Antitoxin

• AlphaFold DB: K9XCG3