Detailed information of TA system TA028543

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 1287032..1287609
• Replicon: chromosome
• Accession: NC_019745
• Organism: Gloeocapsa sp. PCC 7428

Toxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: GLO7428_RS05735
• Protein ID: WP_015187619.1
• Coordinates: 1287032..1287355 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazF
• Uniprot ID: K9XCD0
• Locus tag: GLO7428_RS05740
• Protein ID: WP_015187620.1
• Coordinates: 1287349..1287609 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLO7428_RS05715	1283849..1284073	+	225	WP_015187615.1	hypothetical protein	-
GLO7428_RS05720	1284094..1284519	-	426	WP_015187616.1	TerB family tellurite resistance protein	-
GLO7428_RS05725	1284576..1285916	-	1341	WP_015187617.1	16S rRNA (cytosine(967)-C(5))-methyltransferase	-
GLO7428_RS05730	1285997..1286869	-	873	WP_015187618.1	acyl-CoA desaturase	-
GLO7428_RS05735	1287032..1287355	-	324	WP_015187619.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
GLO7428_RS05740	1287349..1287609	-	261	WP_015187620.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GLO7428_RS05745	1287763..1288968	+	1206	WP_015187621.1	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C-terminal domain	-
GLO7428_RS05750	1288960..1290321	-	1362	WP_015187622.1	alkaline phosphatase family protein	-
GLO7428_RS05755	1290432..1291649	-	1218	WP_015187623.1	metabolite traffic protein EboE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-105)

Antitoxin

• SpoVT-AbrB domain (10-49)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11990.06 Da
• Isoelectric Point: 8.5431

>T28543 WP_015187619.1 NC_019745:c1287355-1287032 [Gloeocapsa sp. PCC 7428]
MVVRRFDVFLVNLDPTIGSEIQKTRPCLVISPNEMNKHIATVIVAPMTTKGQSYPTRVVCQFQGKDGQIVLDQIRTVDKT
RLVKHLGQISLEAQHVVLSTLAEMFAE

Nucleotide

• Length: 324 bp

>T28543 NC_019745:c1287355-1287032 [Gloeocapsa sp. PCC 7428]
ATGGTAGTTAGGCGTTTTGATGTTTTCCTCGTCAATCTTGACCCTACTATTGGTAGTGAAATTCAAAAAACAAGACCTTG
TTTAGTCATATCGCCAAACGAGATGAATAAGCATATTGCAACTGTTATTGTTGCTCCGATGACAACAAAAGGTCAATCTT
ATCCAACACGTGTAGTTTGTCAATTTCAAGGCAAAGATGGACAGATTGTCCTCGATCAAATTCGTACTGTTGACAAAACT
CGCTTGGTCAAACATTTAGGGCAGATTAGTTTAGAAGCACAACACGTAGTTCTTAGTACTTTAGCTGAGATGTTTGCTGA
ATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9745.87 Da
• Isoelectric Point: 4.2457

>AT28543 WP_015187620.1 NC_019745:c1287609-1287349 [Gloeocapsa sp. PCC 7428]
MGTSIKTRIVRIGNSQGIRIPKTLLEQSGISTDVEIELENDHLVIRSASRSRIGWDEAFAAMAEQKDDTLLDDVSTTLWD
QAEWEW

Nucleotide

• Length: 261 bp

>AT28543 NC_019745:c1287609-1287349 [Gloeocapsa sp. PCC 7428]
ATGGGTACAAGTATCAAAACTCGTATAGTGAGAATTGGTAACTCTCAAGGAATTCGCATTCCCAAAACGCTGCTAGAACA
AAGTGGGATTTCCACAGATGTTGAAATCGAACTTGAGAACGATCATTTGGTAATTCGTTCAGCATCGCGATCGCGTATAG
GGTGGGACGAGGCGTTTGCAGCAATGGCAGAACAGAAAGATGATACTTTGTTAGACGATGTGAGTACGACTCTGTGGGAT
CAAGCTGAGTGGGAATGGTAG

Structures

Antitoxin

• AlphaFold DB: K9XCD0