Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 443095..443713 Replicon chromosome
Accession NZ_LM995446
Organism Escherichia coli strain K-12 substr. RV308

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag ECRV308_RS02220 Protein ID WP_001290581.1
Coordinates 443095..443313 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag ECRV308_RS02225 Protein ID WP_000344800.1
Coordinates 443339..443713 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECRV308_RS02190 438384..438956 + 573 WP_000779842.1 YbaY family lipoprotein -
ECRV308_RS02195 438987..439298 - 312 WP_000409911.1 MGMT family protein -
ECRV308_RS02200 439677..440030 + 354 WP_000878140.1 DUF1428 domain-containing protein -
ECRV308_RS02205 440072..441622 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
ECRV308_RS02210 441786..442256 - 471 WP_000136192.1 YlaC family protein -
ECRV308_RS02215 442372..442923 - 552 WP_000102564.1 maltose O-acetyltransferase -
ECRV308_RS02220 443095..443313 - 219 WP_001290581.1 hemolysin expression modulator Hha Toxin
ECRV308_RS02225 443339..443713 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
ECRV308_RS02230 444259..447408 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
ECRV308_RS02235 447431..448624 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8678.06 Da        Isoelectric Point: 8.9008

>T285423 WP_001290581.1 NZ_LM995446:c443313-443095 [Escherichia coli]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT285423 WP_000344800.1 NZ_LM995446:c443713-443339 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References