Detailed information of TA system TA028542

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 32399..32827
• Replicon: chromosome
• Accession: NC_019745
• Organism: Gloeocapsa sp. PCC 7428

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K9X7P2
• Locus tag: GLO7428_RS00165
• Protein ID: WP_015186527.1
• Coordinates: 32606..32827 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: K9X974
• Locus tag: GLO7428_RS00160
• Protein ID: WP_015186526.1
• Coordinates: 32399..32602 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLO7428_RS00140	27610..29295	+	1686	WP_015186522.1	potassium-transporting ATPase subunit A	-
GLO7428_RS00145	29340..31442	+	2103	WP_015186523.1	potassium-transporting ATPase subunit KdpB	-
GLO7428_RS00150	31528..31731	+	204	WP_015186524.1	potassium-transporting ATPase subunit F	-
GLO7428_RS00155	31734..32351	+	618	WP_015186525.1	K(+)-transporting ATPase subunit C	-
GLO7428_RS00160	32399..32602	+	204	WP_015186526.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GLO7428_RS00165	32606..32827	+	222	WP_015186527.1	type II toxin-antitoxin system HicA family toxin	Toxin
GLO7428_RS00170	32991..34163	+	1173	WP_015186528.1	sensor histidine kinase KdpD	-
GLO7428_RS00175	34294..35490	+	1197	WP_041918758.1	anhydro-N-acetylmuramic acid kinase	-
GLO7428_RS00180	35855..37366	+	1512	WP_015186530.1	serine/threonine protein kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-63)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-50)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8361.72 Da
• Isoelectric Point: 10.1836

>T28542 WP_015186527.1 NC_019745:32606-32827 [Gloeocapsa sp. PCC 7428]
MSSIPVLKPQEVVRILENLGFVEVRQKGSHKQFRHTDGPTTVPFHKGRDISPKLLRQIAIDINLTVEEMLESR

Nucleotide

• Length: 222 bp

>T28542 NC_019745:32606-32827 [Gloeocapsa sp. PCC 7428]
ATGAGCAGTATACCTGTTCTCAAACCACAAGAGGTAGTTCGCATCTTGGAGAACCTTGGCTTTGTGGAGGTGCGTCAGAA
AGGCTCACACAAGCAGTTTCGTCATACAGATGGTCCTACGACAGTTCCCTTTCACAAGGGACGCGATATTTCACCTAAGT
TGCTGCGACAAATTGCAATTGATATTAATTTAACAGTTGAAGAGATGTTAGAGTCACGGTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7593.47 Da
• Isoelectric Point: 3.8069

>AT28542 WP_015186526.1 NC_019745:32399-32602 [Gloeocapsa sp. PCC 7428]
MKVFTAIVENSETNLYVGYVPGFPGAHSQGETLDELHENLHEVIEMLLEDQEQVFDTFVGTQQIIIQ

Nucleotide

• Length: 204 bp

>AT28542 NC_019745:32399-32602 [Gloeocapsa sp. PCC 7428]
ATGAAAGTGTTTACCGCTATTGTTGAGAATTCAGAGACTAACCTCTATGTAGGTTATGTACCTGGATTTCCTGGAGCGCA
CTCTCAAGGAGAAACCTTGGACGAGTTACACGAGAATCTGCATGAGGTCATTGAAATGCTTCTGGAGGATCAAGAACAAG
TGTTCGATACATTCGTCGGCACGCAACAGATTATTATCCAGTAA

Structures

Toxin

• AlphaFold DB: K9X7P2

Antitoxin

• AlphaFold DB: K9X974