Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 14798..15841 | Replicon | plasmid pCRI9333.05 |
| Accession | NC_019736 | ||
| Organism | Crinalium epipsammum PCC 9333 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | CRI9333_RS24140 | Protein ID | WP_015180063.1 |
| Coordinates | 15272..15841 (+) | Length | 190 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | K9W7G4 |
| Locus tag | CRI9333_RS24135 | Protein ID | WP_015180062.1 |
| Coordinates | 14798..15265 (+) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CRI9333_RS24115 | 10035..11954 | + | 1920 | WP_015180058.1 | DEAD/DEAH box helicase | - |
| CRI9333_RS24120 | 12265..12582 | + | 318 | WP_015180059.1 | type II toxin-antitoxin system HigB family toxin | - |
| CRI9333_RS24125 | 12653..13048 | + | 396 | WP_015180060.1 | transcriptional regulator | - |
| CRI9333_RS24130 | 13062..14048 | - | 987 | WP_015180061.1 | tyrosine-type recombinase/integrase | - |
| CRI9333_RS24135 | 14798..15265 | + | 468 | WP_015180062.1 | excisionase family DNA-binding protein | Antitoxin |
| CRI9333_RS24140 | 15272..15841 | + | 570 | WP_015180063.1 | PIN domain-containing protein | Toxin |
| CRI9333_RS24145 | 16394..16726 | + | 333 | WP_015180064.1 | hypothetical protein | - |
| CRI9333_RS27100 | 17162..17317 | - | 156 | WP_157462502.1 | hypothetical protein | - |
| CRI9333_RS27105 | 17391..17510 | + | 120 | Protein_20 | IS4 family transposase | - |
| CRI9333_RS24150 | 17670..17993 | - | 324 | WP_015180065.1 | hypothetical protein | - |
| CRI9333_RS24155 | 18193..18879 | - | 687 | WP_015180066.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..39142 | 39142 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 190 a.a. Molecular weight: 21389.89 Da Isoelectric Point: 5.0201
>T28539 WP_015180063.1 NC_019736:15272-15841 [Crinalium epipsammum PCC 9333]
VATFTAVYDACVLYPAPLRDFLMWLALTDLFKARWTEEIHAEWIRNVLLNRPDLTIEQLTRTKNLMNANVRDCLVTGYSE
LIPSLELKDPGDRHVLAAAICCHADFIVTFNLKDFPEQALAPKFIEAIHPDEFIKQLIDLNPVAVCAAALRQRTSLKNPQ
LTRQEYLDTLALLGLTLSVAALRDLCQEI
VATFTAVYDACVLYPAPLRDFLMWLALTDLFKARWTEEIHAEWIRNVLLNRPDLTIEQLTRTKNLMNANVRDCLVTGYSE
LIPSLELKDPGDRHVLAAAICCHADFIVTFNLKDFPEQALAPKFIEAIHPDEFIKQLIDLNPVAVCAAALRQRTSLKNPQ
LTRQEYLDTLALLGLTLSVAALRDLCQEI
Download Length: 570 bp
>T28539 NC_019736:15272-15841 [Crinalium epipsammum PCC 9333]
GTGGCTACTTTTACGGCGGTCTACGATGCTTGTGTTTTATATCCAGCACCACTGAGAGATTTTTTGATGTGGTTGGCGCT
GACAGATTTATTTAAGGCTCGTTGGACAGAAGAAATTCATGCTGAGTGGATCAGAAATGTTCTCTTAAACCGTCCAGATC
TAACAATAGAGCAGCTAACCAGAACTAAAAACTTGATGAATGCTAATGTCCGAGATTGTTTGGTGACAGGTTATTCAGAG
CTAATCCCAAGTCTTGAACTCAAAGATCCAGGCGATCGCCATGTTTTGGCAGCAGCAATTTGTTGTCATGCTGATTTCAT
CGTTACTTTCAACCTGAAAGACTTTCCAGAACAGGCACTTGCACCAAAATTTATTGAAGCTATTCACCCAGACGAGTTTA
TTAAACAGTTGATTGACCTCAATCCAGTAGCGGTTTGTGCCGCAGCTTTAAGGCAAAGAACATCTCTTAAAAATCCACAG
TTAACGCGCCAAGAGTATTTAGATACACTTGCACTACTTGGATTAACGTTGTCAGTTGCGGCACTGCGGGATTTGTGTCA
GGAGATTTAG
GTGGCTACTTTTACGGCGGTCTACGATGCTTGTGTTTTATATCCAGCACCACTGAGAGATTTTTTGATGTGGTTGGCGCT
GACAGATTTATTTAAGGCTCGTTGGACAGAAGAAATTCATGCTGAGTGGATCAGAAATGTTCTCTTAAACCGTCCAGATC
TAACAATAGAGCAGCTAACCAGAACTAAAAACTTGATGAATGCTAATGTCCGAGATTGTTTGGTGACAGGTTATTCAGAG
CTAATCCCAAGTCTTGAACTCAAAGATCCAGGCGATCGCCATGTTTTGGCAGCAGCAATTTGTTGTCATGCTGATTTCAT
CGTTACTTTCAACCTGAAAGACTTTCCAGAACAGGCACTTGCACCAAAATTTATTGAAGCTATTCACCCAGACGAGTTTA
TTAAACAGTTGATTGACCTCAATCCAGTAGCGGTTTGTGCCGCAGCTTTAAGGCAAAGAACATCTCTTAAAAATCCACAG
TTAACGCGCCAAGAGTATTTAGATACACTTGCACTACTTGGATTAACGTTGTCAGTTGCGGCACTGCGGGATTTGTGTCA
GGAGATTTAG
Antitoxin
Download Length: 156 a.a. Molecular weight: 16948.59 Da Isoelectric Point: 8.3520
>AT28539 WP_015180062.1 NC_019736:14798-15265 [Crinalium epipsammum PCC 9333]
MTVSTDRSVSAIAPTEKDATEAGAARRVLASYSLPQPLHALKLILDDATGSTVTIPAAAYKLLVEILAQMAEGNAVSIVP
IKKEITTQEAADILNVSRPYFVKLLESGKIPYRKVGTRRRVLTTDVLDYKNQIDTQRMQTLMELAAQAQELNMGY
MTVSTDRSVSAIAPTEKDATEAGAARRVLASYSLPQPLHALKLILDDATGSTVTIPAAAYKLLVEILAQMAEGNAVSIVP
IKKEITTQEAADILNVSRPYFVKLLESGKIPYRKVGTRRRVLTTDVLDYKNQIDTQRMQTLMELAAQAQELNMGY
Download Length: 468 bp
>AT28539 NC_019736:14798-15265 [Crinalium epipsammum PCC 9333]
ATGACAGTTTCAACAGACCGTTCTGTTTCTGCGATCGCACCCACCGAAAAAGATGCGACGGAAGCGGGTGCTGCTAGGAG
AGTATTGGCATCATATTCGCTTCCTCAACCATTGCACGCGCTCAAGCTGATACTAGATGATGCGACTGGTTCAACGGTGA
CTATACCAGCCGCCGCTTACAAGTTGCTGGTAGAAATTCTGGCACAGATGGCTGAAGGTAATGCCGTTAGCATTGTCCCA
ATTAAGAAGGAAATCACTACCCAAGAAGCGGCTGATATCCTGAATGTCTCTCGTCCTTATTTTGTTAAATTACTTGAGTC
AGGGAAAATTCCTTACCGGAAAGTGGGAACACGTCGTCGGGTGCTAACTACTGATGTACTTGATTACAAAAACCAGATTG
ATACGCAAAGGATGCAGACTCTTATGGAACTAGCTGCCCAAGCCCAAGAATTGAATATGGGATACTAA
ATGACAGTTTCAACAGACCGTTCTGTTTCTGCGATCGCACCCACCGAAAAAGATGCGACGGAAGCGGGTGCTGCTAGGAG
AGTATTGGCATCATATTCGCTTCCTCAACCATTGCACGCGCTCAAGCTGATACTAGATGATGCGACTGGTTCAACGGTGA
CTATACCAGCCGCCGCTTACAAGTTGCTGGTAGAAATTCTGGCACAGATGGCTGAAGGTAATGCCGTTAGCATTGTCCCA
ATTAAGAAGGAAATCACTACCCAAGAAGCGGCTGATATCCTGAATGTCTCTCGTCCTTATTTTGTTAAATTACTTGAGTC
AGGGAAAATTCCTTACCGGAAAGTGGGAACACGTCGTCGGGTGCTAACTACTGATGTACTTGATTACAAAAACCAGATTG
ATACGCAAAGGATGCAGACTCTTATGGAACTAGCTGCCCAAGCCCAAGAATTGAATATGGGATACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|