Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1182656..1184412 Replicon chromosome
Accession NZ_LK936443
Organism Burkholderia pseudomallei strain C1

Toxin (Protein)


Gene name doc Uniprot ID Q3JFK6
Locus tag BP3921G_RS22875 Protein ID WP_004528160.1
Coordinates 1182656..1183561 (+) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q63LW2
Locus tag BP3921G_RS22880 Protein ID WP_004195450.1
Coordinates 1183558..1184412 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BP3921G_RS22845 1178051..1179139 - 1089 WP_004184835.1 porin -
BP3921G_RS22850 1179574..1179891 + 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
BP3921G_RS22855 1179893..1180204 + 312 WP_004528159.1 hypothetical protein -
BP3921G_RS22860 1180239..1181306 + 1068 WP_004195457.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BP3921G_RS22865 1181303..1182073 + 771 WP_004524000.1 SDR family oxidoreductase -
BP3921G_RS22870 1182112..1182639 + 528 WP_004524001.1 cupin domain-containing protein -
BP3921G_RS22875 1182656..1183561 + 906 WP_004528160.1 alpha/beta fold hydrolase Toxin
BP3921G_RS22880 1183558..1184412 + 855 WP_004195450.1 IclR family transcriptional regulator Antitoxin
BP3921G_RS22885 1184409..1185206 + 798 WP_004528161.1 SDR family oxidoreductase -
BP3921G_RS22890 1185199..1186872 + 1674 WP_004524004.1 thiamine pyrophosphate-binding protein -
BP3921G_RS22895 1186865..1187680 + 816 WP_004528162.1 aspartate dehydrogenase -
BP3921G_RS22900 1187706..1189196 + 1491 WP_004524006.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-284)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30586.71 Da        Isoelectric Point: 8.4944

>T285385 WP_004528160.1 NZ_LK936443:1182656-1183561 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSTNMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP

Download         Length: 906 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31152.56 Da        Isoelectric Point: 6.8932

>AT285385 WP_004195450.1 NZ_LK936443:1183558-1184412 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4FRW8

References