Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 549730..550691 Replicon chromosome
Accession NZ_LK021129
Organism Vibrio anguillarum strain NB10

Toxin (Protein)


Gene name - Uniprot ID F7YRB7
Locus tag VANGNB10_RS02825 Protein ID WP_013868567.1
Coordinates 549730..550263 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag VANGNB10_RS20760 Protein ID WP_013868568.1
Coordinates 550260..550691 (-) Length 144 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VANGNB10_RS02795 545399..545752 - 354 WP_011154649.1 IS66 family insertion sequence element accessory protein TnpB -
VANGNB10_RS02800 545749..546066 - 318 WP_011154648.1 IS66 family insertion sequence hypothetical protein -
VANGNB10_RS02805 546224..546880 - 657 WP_013868559.1 hypothetical protein -
VANGNB10_RS20205 546920..547036 - 117 WP_080749045.1 DUF3265 domain-containing protein -
VANGNB10_RS02810 547033..547377 - 345 WP_013868560.1 hypothetical protein -
VANGNB10_RS02815 547528..548076 - 549 WP_019281391.1 hypothetical protein -
VANGNB10_RS20210 548130..548255 - 126 WP_013868562.1 DUF3265 domain-containing protein -
VANGNB10_RS02820 548763..549044 - 282 WP_029190024.1 hypothetical protein -
VANGNB10_RS02825 549730..550263 - 534 WP_013868567.1 GNAT family N-acetyltransferase Toxin
VANGNB10_RS20760 550260..550691 - 432 WP_013868568.1 DUF1778 domain-containing protein Antitoxin
VANGNB10_RS02835 551210..551725 - 516 WP_013868571.1 GNAT family N-acetyltransferase -
VANGNB10_RS20225 551763..551855 - 93 WP_072600976.1 DUF3265 domain-containing protein -
VANGNB10_RS02840 551970..552938 + 969 WP_080749032.1 IS30-like element ISVa6 family transposase -
VANGNB10_RS02845 552980..553294 - 315 WP_006073510.1 hypothetical protein -
VANGNB10_RS02850 553836..555269 + 1434 Protein_514 DEAD/DEAH box helicase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron qnrVC6 - 541158..552938 11780
- inside Integron - - 541158..552938 11780


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(97-153)

Antitoxin

(59-135)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 20222.47 Da        Isoelectric Point: 9.1188

>T285382 WP_013868567.1 NZ_LK021129:c550263-549730 [Vibrio anguillarum]
VSWGREFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSGQPLLNQKFAICAFYSVAPSSISRETLPT
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMYLPMKTVEQLFNQ

Download         Length: 534 bp


Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15859.40 Da        Isoelectric Point: 7.0831

>AT285382 WP_013868568.1 NZ_LK021129:c550691-550260 [Vibrio anguillarum]
VFTVCFLSSAVRCQPLSRALYSPSFRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLG
LKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 432 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A241NLG3


Antitoxin

Source ID Structure

References