Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 475694..476460 Replicon chromosome
Accession NZ_LK021129
Organism Vibrio anguillarum strain NB10

Toxin (Protein)


Gene name - Uniprot ID F7YRS3
Locus tag VANGNB10_RS02350 Protein ID WP_013867769.1
Coordinates 475694..476191 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID F7YRS4
Locus tag VANGNB10_RS02355 Protein ID WP_013867770.1
Coordinates 476188..476460 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VANGNB10_RS02325 472163..472516 - 354 WP_011154649.1 IS66 family insertion sequence element accessory protein TnpB -
VANGNB10_RS02330 472513..472830 - 318 WP_011154648.1 IS66 family insertion sequence hypothetical protein -
VANGNB10_RS20165 472945..473037 + 93 WP_019281220.1 DUF3265 domain-containing protein -
VANGNB10_RS20170 473125..473331 + 207 WP_013867765.1 DUF1289 domain-containing protein -
VANGNB10_RS02335 473451..473681 - 231 WP_013867766.1 PAS factor family protein -
VANGNB10_RS02340 473975..474211 - 237 WP_013867767.1 hypothetical protein -
VANGNB10_RS02345 474496..474984 + 489 WP_013867768.1 hypothetical protein -
VANGNB10_RS20575 474975..475106 + 132 Protein_410 DUF3265 domain-containing protein -
VANGNB10_RS02350 475694..476191 - 498 WP_013867769.1 GNAT family N-acetyltransferase Toxin
VANGNB10_RS02355 476188..476460 - 273 WP_013867770.1 DUF1778 domain-containing protein Antitoxin
VANGNB10_RS02365 477211..477930 + 720 Protein_413 hypothetical protein -
VANGNB10_RS02370 477987..478907 - 921 WP_011154643.1 IS5-like element ISVa2 family transposase -
VANGNB10_RS02375 479012..479299 + 288 WP_157727321.1 potassium channel family protein -
VANGNB10_RS02380 479325..480293 - 969 WP_080749032.1 IS30-like element ISVa6 family transposase -
VANGNB10_RS02385 480666..481055 + 390 WP_019280976.1 DUF1090 domain-containing protein -
VANGNB10_RS20180 481059..481148 + 90 WP_019280977.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 436076..481055 44979


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18525.25 Da        Isoelectric Point: 9.2555

>T285381 WP_013867769.1 NZ_LK021129:c476191-475694 [Vibrio anguillarum]
MMNTVLLDKVKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSSHIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKYFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9731.18 Da        Isoelectric Point: 8.6154

>AT285381 WP_013867770.1 NZ_LK021129:c476460-476188 [Vibrio anguillarum]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAILLMDALDRPTAQNSKLRA
ASERYESKAQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y3QZT4

Antitoxin

Source ID Structure
AlphaFold DB A0A7X8U164

References