Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 492223..492815 Replicon chromosome
Accession NZ_LC127084
Organism Edwardsiella tarda strain ET-1

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag SAMD00131843_RS02165 Protein ID WP_012847872.1
Coordinates 492223..492426 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D0ZEC3
Locus tag SAMD00131843_RS02170 Protein ID WP_012847873.1
Coordinates 492447..492815 (-) Length 123 a.a.

Genomic Context

SAMD00131843_RS02130SAMD00131843_RS02135SAMD00131843_RS02140SAMD00131843_RS02145SAMD00131843_RS02150SAMD00131843_RS02165SAMD00131843_RS02170SAMD00131843_RS02175SAMD00131843_RS02180
Location: 487886..488347 (462 bp)
Type: Others
Protein ID: WP_012847865.1
Location: 488652..488990 (339 bp)
Type: Others
Protein ID: WP_012847867.1
Location: 489012..490292 (1281 bp)
Type: Others
Protein ID: WP_041692495.1
Location: 490327..491193 (867 bp)
Type: Others
Protein ID: WP_012847869.1
Location: 491302..491658 (357 bp)
Type: Others
Protein ID: WP_012847870.1
Location: 492223..492426 (204 bp)
Type: Toxin
Protein ID: WP_012847872.1
Location: 492447..492815 (369 bp)
Type: Antitoxin
Protein ID: WP_012847873.1
Location: 493183..496335 (3153 bp)
Type: Others
Protein ID: WP_012847874.1
Location: 496379..497563 (1185 bp)
Type: Others
Protein ID: WP_012847875.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SAMD00131843_RS02130487886..488347+462WP_012847865.1Lrp/AsnC family transcriptional regulator-
SAMD00131843_RS02135488652..488990+339WP_012847867.1P-II family nitrogen regulator-
SAMD00131843_RS02140489012..490292+1281WP_041692495.1ammonium transporter AmtB-
SAMD00131843_RS02145490327..491193-867WP_012847869.1acyl-CoA thioesterase II-
SAMD00131843_RS02150491302..491658-357WP_012847870.1MGMT family protein-
SAMD00131843_RS02165492223..492426-204WP_012847872.1hemolysin expression modulator HhaToxin
SAMD00131843_RS02170492447..492815-369WP_012847873.1Hha toxicity modulator TomBAntitoxin
SAMD00131843_RS02175493183..496335-3153WP_012847874.1multidrug efflux RND transporter permease subunit-
SAMD00131843_RS02180496379..497563-1185WP_012847875.1efflux RND transporter periplasmic adaptor subunit-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T285371 WP_012847872.1 NZ_LC127084:c492426-492223 [Edwardsiella tarda]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14129.83 Da        Isoelectric Point: 6.1484

>AT285371 WP_012847873.1 NZ_LC127084:c492815-492447 [Edwardsiella tarda]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNATLHV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A034SMG4

Antitoxin

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Source
ID
Structure
AlphaFold DBD0ZEC3

References