285368

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 702644..703121 Replicon chromosome
Accession NZ_JPPU01000009
Organism Staphylococcus aureus strain HG003 isolate RN1 Scaffold_9

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag IM26_RS24295 Protein ID WP_000052078.1
Coordinates 702933..703121 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IM26_RS24290 Protein ID WP_001059690.1
Coordinates 702644..702904 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM26_RS24255 (IM26_09425) 698037..698753 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
IM26_RS24260 (IM26_09430) 698901..699323 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IM26_RS24265 (IM26_09435) 699722..700216 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IM26_RS24270 (IM26_09440) 700371..700988 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IM26_RS24275 (IM26_09445) 701061..701642 - 582 WP_001140693.1 histidine phosphatase family protein -
IM26_RS24280 (IM26_09450) 701867..702103 + 237 WP_000368687.1 hypothetical protein -
IM26_RS24285 (IM26_09455) 702100..702303 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IM26_RS24290 (IM26_09460) 702644..702904 + 261 WP_001059690.1 hypothetical protein Antitoxin
IM26_RS24295 (IM26_09465) 702933..703121 + 189 WP_000052078.1 hypothetical protein Toxin
IM26_RS24300 (IM26_09470) 703309..703878 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IM26_RS24305 (IM26_09475) 703966..704250 + 285 WP_001004395.1 hypothetical protein -
IM26_RS24310 (IM26_09480) 704312..704530 + 219 WP_000005886.1 hypothetical protein -
IM26_RS24315 (IM26_09485) 705026..705226 - 201 WP_001059082.1 cold-shock protein -
IM26_RS24320 (IM26_09490) 705583..706269 - 687 WP_001548082.1 thermonuclease family protein -
IM26_RS24325 (IM26_09495) 706610..707080 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T285368 WP_000052078.1 NZ_JPPU01000009:702933-703121 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T285368 NZ_JPPU01000009:702933-703121 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT285368 WP_001059690.1 NZ_JPPU01000009:702644-702904 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT285368 NZ_JPPU01000009:702644-702904 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References