Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 82081..82595 Replicon chromosome
Accession NZ_JPPU01000003
Organism Staphylococcus aureus strain HG003 isolate RN1 Scaffold_3

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IM26_RS17965 Protein ID WP_000581792.1
Coordinates 82386..82595 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IM26_RS17960 Protein ID WP_000138932.1
Coordinates 82081..82374 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM26_RS17940 (IM26_02810) 77344..77985 + 642 WP_000483153.1 thiamine phosphate synthase -
IM26_RS17945 (IM26_02815) 78071..78943 + 873 WP_000725802.1 membrane protein insertase YidC -
IM26_RS17950 (IM26_02820) 79756..80403 - 648 WP_001187629.1 HD domain-containing protein -
IM26_RS17955 (IM26_02825) 80431..81915 - 1485 WP_000571549.1 cardiolipin synthase -
IM26_RS17960 (IM26_02830) 82081..82374 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IM26_RS17965 (IM26_02835) 82386..82595 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IM26_RS0113865 82723..82860 + 138 WP_000828354.1 Lmo0850 family protein -
IM26_RS17970 (IM26_02845) 83124..84326 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IM26_RS17975 (IM26_02850) 84644..85714 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IM26_RS17980 (IM26_02855) 85729..87087 + 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T285362 WP_000581792.1 NZ_JPPU01000003:82386-82595 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T285362 NZ_JPPU01000003:82386-82595 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT285362 WP_000138932.1 NZ_JPPU01000003:82081-82374 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT285362 NZ_JPPU01000003:82081-82374 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References