Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4616557..4617054 Replicon chromosome
Accession NZ_HG994851
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LLO82_RS22375 Protein ID WP_001173343.1
Coordinates 4616557..4616730 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag LLO82_RS22380 Protein ID WP_001312331.1
Coordinates 4616758..4617054 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO82_RS22365 (4613227) 4613227..4614684 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
LLO82_RS22370 (4614921) 4614921..4616438 + 1518 WP_000003805.1 lysine--tRNA ligase -
LLO82_RS22375 (4616557) 4616557..4616730 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LLO82_RS22380 (4616758) 4616758..4617054 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LLO82_RS22385 (4617283) 4617283..4617555 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
LLO82_RS22390 (4617567) 4617567..4617797 - 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
LLO82_RS22395 (4617978) 4617978..4619609 + 1632 WP_001216466.1 sensor histidine kinase -
LLO82_RS22400 (4619606) 4619606..4620325 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T285337 WP_001173343.1 NZ_HG994851:c4616730-4616557 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT285337 WP_001312331.1 NZ_HG994851:c4617054-4616758 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References