Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3648813..3649431 Replicon chromosome
Accession NZ_HG994851
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LLO82_RS17625 Protein ID WP_001291435.1
Coordinates 3649213..3649431 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LLO82_RS17620 Protein ID WP_000344800.1
Coordinates 3648813..3649187 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO82_RS17610 (3643903) 3643903..3645096 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LLO82_RS17615 (3645119) 3645119..3648268 + 3150 WP_001132481.1 efflux RND transporter permease AcrB -
LLO82_RS17620 (3648813) 3648813..3649187 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LLO82_RS17625 (3649213) 3649213..3649431 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LLO82_RS17630 (3649605) 3649605..3650156 + 552 WP_000102539.1 maltose O-acetyltransferase -
LLO82_RS17635 (3650272) 3650272..3650742 + 471 WP_000136192.1 YlaC family protein -
LLO82_RS17640 (3650906) 3650906..3652456 + 1551 WP_001298569.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LLO82_RS17645 (3652498) 3652498..3652851 - 354 WP_000878138.1 DUF1428 family protein -
LLO82_RS17655 (3653230) 3653230..3653541 + 312 WP_000409908.1 MGMT family protein -
LLO82_RS17660 (3653572) 3653572..3654144 - 573 WP_000779830.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T285327 WP_001291435.1 NZ_HG994851:3649213-3649431 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT285327 WP_000344800.1 NZ_HG994851:3648813-3649187 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References