Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2508240..2509828 Replicon chromosome
Accession NZ_HG994851
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name hipA Uniprot ID A0A192ENQ5
Locus tag LLO82_RS11920 Protein ID WP_001125432.1
Coordinates 2508506..2509828 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V0VAH2
Locus tag LLO82_RS11915 Protein ID WP_001304368.1
Coordinates 2508240..2508506 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO82_RS11900 (2504608) 2504608..2506059 + 1452 WP_000854642.1 tagaturonate reductase -
LLO82_RS11905 (2506256) 2506256..2507170 + 915 WP_001298637.1 bestrophin family protein -
LLO82_RS11910 (2507174) 2507174..2507932 - 759 WP_001286538.1 trans-aconitate 2-methyltransferase -
LLO82_RS11915 (2508240) 2508240..2508506 + 267 WP_001304368.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LLO82_RS11920 (2508506) 2508506..2509828 + 1323 WP_001125432.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
LLO82_RS11925 (2510004) 2510004..2510696 - 693 WP_000382466.1 hypothetical protein -
LLO82_RS11930 (2510708) 2510708..2510983 - 276 WP_000948310.1 hypothetical protein -
LLO82_RS11935 (2510985) 2510985..2511125 - 141 WP_001335097.1 hypothetical protein -
LLO82_RS11940 (2511241) 2511241..2511423 - 183 WP_001335098.1 hypothetical protein -
LLO82_RS11945 (2511593) 2511593..2512645 + 1053 WP_000568119.1 phage/plasmid replication protein, II/X family -
LLO82_RS11950 (2512657) 2512657..2512974 + 318 WP_000073834.1 DNA-binding protein -
LLO82_RS11960 (2513178) 2513178..2513420 + 243 WP_000699011.1 phage capsid protein -
LLO82_RS11965 (2513467) 2513467..2514747 + 1281 WP_000823306.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49297.02 Da        Isoelectric Point: 8.6972

>T285322 WP_001125432.1 NZ_HG994851:2508506-2509828 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9957.31 Da        Isoelectric Point: 4.9632

>AT285322 WP_001304368.1 NZ_HG994851:2508240-2508506 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192ENQ5

Antitoxin

Source ID Structure
AlphaFold DB V0VAH2

References