Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-ChpS
Location 2391797..2392383 Replicon chromosome
Accession NC_019702
Organism Synechococcus sp. PCC 7502

Toxin (Protein)


Gene name pemK Uniprot ID K9SX69
Locus tag SYN7502_RS11810 Protein ID WP_015169044.1
Coordinates 2392048..2392383 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID K9SW06
Locus tag SYN7502_RS11805 Protein ID WP_015169043.1
Coordinates 2391797..2392051 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SYN7502_RS11785 2387536..2387931 - 396 WP_015169038.1 PH domain-containing protein -
SYN7502_RS11790 2387974..2388330 - 357 WP_015169039.1 ribonuclease P protein component -
SYN7502_RS18965 2388365..2388505 - 141 WP_015169040.1 50S ribosomal protein L34 -
SYN7502_RS11795 2388690..2391326 + 2637 WP_015169041.1 efflux RND transporter permease subunit -
SYN7502_RS18380 2391345..2391737 + 393 WP_015169042.1 heterocyst frequency control protein PatD -
SYN7502_RS11805 2391797..2392051 + 255 WP_015169043.1 growth regulator Antitoxin
SYN7502_RS11810 2392048..2392383 + 336 WP_015169044.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SYN7502_RS11815 2392384..2393151 - 768 WP_015169045.1 imidazole glycerol phosphate synthase subunit HisF -
SYN7502_RS11820 2393135..2393815 + 681 WP_015169046.1 hypothetical protein -
SYN7502_RS11825 2393836..2394477 - 642 WP_015169047.1 Uma2 family endonuclease -
SYN7502_RS11830 2394527..2395993 + 1467 WP_210391404.1 mechanosensitive ion channel -
SYN7502_RS11835 2396219..2396722 - 504 WP_015169049.1 cyclic pyranopterin monophosphate synthase MoaC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 11897.82 Da        Isoelectric Point: 9.2725

>T28532 WP_015169044.1 NC_019702:2392048-2392383 [Synechococcus sp. PCC 7502]
MKRGDIYLVSLDPSAGHEQQGTRPVLIVSPDKFNAVTKVPIVVPITSGGNFARSAGFAVPLAGIDIRTKGVVRCDQPRSL
DLGARSARKLESVPEVIIEEVLAKICTLFNN

Download         Length: 336 bp

>T28532 NC_019702:2392048-2392383 [Synechococcus sp. PCC 7502]
ATGAAGAGAGGTGATATTTATCTGGTTTCGCTTGATCCCTCAGCAGGACATGAGCAACAGGGAACTAGACCAGTTCTTAT
AGTTTCACCCGATAAATTTAACGCTGTAACCAAAGTGCCGATTGTGGTGCCAATTACCTCAGGTGGAAATTTTGCCCGTT
CCGCAGGTTTTGCAGTTCCCTTGGCAGGGATAGACATTCGTACTAAAGGTGTTGTGAGGTGTGATCAGCCTAGGTCGCTA
GATTTAGGAGCTAGATCAGCTCGGAAACTAGAAAGTGTTCCCGAAGTTATCATAGAAGAGGTTTTAGCTAAAATTTGCAC
TTTGTTTAATAACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9225.65 Da        Isoelectric Point: 4.0233

>AT28532 WP_015169043.1 NC_019702:2391797-2392051 [Synechococcus sp. PCC 7502]
MYKTNLRKVGGSIMLAVPPSLLDMLQLQAGSTVGITVDDGKVIVTPQLKPAYSLDELLEQCDPNAPITNEDQEWFDLRPI
GLEL

Download         Length: 255 bp

>AT28532 NC_019702:2391797-2392051 [Synechococcus sp. PCC 7502]
ATGTACAAAACAAATTTACGCAAAGTAGGTGGATCAATTATGTTAGCGGTGCCGCCATCACTGCTTGATATGTTGCAGCT
TCAGGCTGGATCAACTGTGGGAATTACCGTTGATGATGGGAAAGTTATTGTGACCCCACAACTAAAACCTGCTTATTCCC
TAGATGAATTGTTAGAACAATGTGACCCAAATGCTCCGATTACAAATGAAGATCAAGAGTGGTTTGATTTGAGACCCATA
GGGCTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K9SX69

Antitoxin

Source ID Structure
AlphaFold DB K9SW06

References