Detailed information of TA system TA028531

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 1573116..1573759
• Replicon: chromosome
• Accession: NC_019702
• Organism: Synechococcus sp. PCC 7502

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SYN7502_RS07760
• Protein ID: WP_041429318.1
• Coordinates: 1573116..1573517 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K9STT6
• Locus tag: SYN7502_RS07765
• Protein ID: WP_015168296.1
• Coordinates: 1573514..1573759 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYN7502_RS07730	1568376..1569065	+	690	WP_015168289.1	hypothetical protein	-
SYN7502_RS07735	1569141..1569599	+	459	WP_015168290.1	hypothetical protein	-
SYN7502_RS07740	1569773..1570564	-	792	WP_015168291.1	hypothetical protein	-
SYN7502_RS07745	1570650..1571051	-	402	WP_041430039.1	hypothetical protein	-
SYN7502_RS07750	1571280..1571474	+	195	WP_168130339.1	hypothetical protein	-
SYN7502_RS07755	1571595..1572815	-	1221	WP_015168294.1	heavy metal-binding domain-containing protein	-
SYN7502_RS07760	1573116..1573517	-	402	WP_041429318.1	type II toxin-antitoxin system VapC family toxin	Toxin
SYN7502_RS07765	1573514..1573759	-	246	WP_015168296.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SYN7502_RS07770	1573925..1574749	+	825	WP_015168297.1	zinc-dependent peptidase	-
SYN7502_RS07775	1575186..1575887	+	702	WP_015168298.1	hypothetical protein	-
SYN7502_RS07780	1575868..1576632	-	765	WP_015168299.1	SIMPL domain-containing protein	-
SYN7502_RS07785	1576758..1577873	+	1116	WP_015168300.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-47)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15007.29 Da
• Isoelectric Point: 4.3619

>T28531 WP_041429318.1 NC_019702:c1573517-1573116 [Synechococcus sp. PCC 7502]
VKLLMDTHCWLWWFSQPELLSEEAIACIVDEANEVWFSVASVWEMGIKVAIGKLPLPEPLDSYISSRMVQLGARSLDISV
NHAIQAAALPLHHRDPFDRLLIAQAQIENMTIVTADNMFSQYQDISILWAANS

Nucleotide

• Length: 402 bp

>T28531 NC_019702:c1573517-1573116 [Synechococcus sp. PCC 7502]
GTGAAACTTCTAATGGATACTCATTGCTGGTTGTGGTGGTTTTCTCAGCCAGAGCTTCTTAGCGAGGAGGCGATCGCTTG
TATTGTTGATGAAGCTAATGAAGTGTGGTTCTCTGTGGCAAGTGTGTGGGAAATGGGTATTAAAGTAGCGATCGGCAAGT
TGCCATTACCAGAACCATTAGATAGCTATATATCAAGTCGCATGGTGCAATTGGGAGCAAGATCACTTGACATTTCAGTT
AACCATGCTATCCAAGCTGCGGCTTTGCCTTTACATCATCGCGATCCATTCGACAGACTCTTAATCGCACAAGCTCAAAT
AGAAAATATGACGATTGTGACGGCTGATAATATGTTTAGTCAATATCAAGACATTTCTATCCTTTGGGCAGCAAATTCAT
AG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8836.04 Da
• Isoelectric Point: 5.0508

>AT28531 WP_015168296.1 NC_019702:c1573759-1573514 [Synechococcus sp. PCC 7502]
METVNIHQAKTNLSRLLSRVELGEEIVISNRGIPVAKLVPFSTSSNRKASLGIDRGRFIVPEDFNAPLPEDILSAFEGSE
G

Nucleotide

• Length: 246 bp

>AT28531 NC_019702:c1573759-1573514 [Synechococcus sp. PCC 7502]
ATGGAAACTGTTAATATTCATCAGGCTAAAACCAATCTTTCACGCCTTTTGTCGAGGGTAGAACTTGGGGAAGAGATTGT
TATTTCTAATCGAGGTATTCCTGTGGCTAAGCTAGTGCCATTTTCTACTTCTTCTAATCGTAAGGCTAGTTTAGGGATAG
ATCGGGGAAGGTTTATTGTGCCTGAAGACTTTAACGCTCCTTTGCCAGAAGATATTTTGTCAGCATTTGAGGGTAGTGAA
GGGTGA

Structures

Antitoxin

• AlphaFold DB: K9STT6