Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4669410..4669907 Replicon chromosome
Accession NZ_HG994850
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LLO83_RS22585 Protein ID WP_001173343.1
Coordinates 4669410..4669583 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag LLO83_RS22590 Protein ID WP_001312331.1
Coordinates 4669611..4669907 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO83_RS22575 (4666080) 4666080..4667537 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
LLO83_RS22580 (4667774) 4667774..4669291 + 1518 WP_000003805.1 lysine--tRNA ligase -
LLO83_RS22585 (4669410) 4669410..4669583 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LLO83_RS22590 (4669611) 4669611..4669907 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LLO83_RS22595 (4670136) 4670136..4670408 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
LLO83_RS22600 (4670420) 4670420..4670650 - 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
LLO83_RS22605 (4670831) 4670831..4672462 + 1632 WP_001216466.1 sensor histidine kinase -
LLO83_RS22610 (4672459) 4672459..4673178 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T285309 WP_001173343.1 NZ_HG994850:c4669583-4669410 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT285309 WP_001312331.1 NZ_HG994850:c4669907-4669611 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References