Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3672301..3672919 Replicon chromosome
Accession NZ_HG994850
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LLO83_RS17715 Protein ID WP_001291435.1
Coordinates 3672701..3672919 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LLO83_RS17710 Protein ID WP_000344800.1
Coordinates 3672301..3672675 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO83_RS17700 (3667391) 3667391..3668584 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LLO83_RS17705 (3668607) 3668607..3671756 + 3150 WP_001132481.1 efflux RND transporter permease AcrB -
LLO83_RS17710 (3672301) 3672301..3672675 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LLO83_RS17715 (3672701) 3672701..3672919 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LLO83_RS17720 (3673093) 3673093..3673644 + 552 WP_000102539.1 maltose O-acetyltransferase -
LLO83_RS17725 (3673760) 3673760..3674230 + 471 WP_000136192.1 YlaC family protein -
LLO83_RS17730 (3674394) 3674394..3675944 + 1551 WP_001298569.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LLO83_RS17735 (3675986) 3675986..3676339 - 354 WP_000878138.1 DUF1428 family protein -
LLO83_RS17745 (3676718) 3676718..3677029 + 312 WP_000409908.1 MGMT family protein -
LLO83_RS17750 (3677060) 3677060..3677632 - 573 WP_000779830.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T285299 WP_001291435.1 NZ_HG994850:3672701-3672919 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT285299 WP_000344800.1 NZ_HG994850:3672301-3672675 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References