Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 974955..975609 Replicon chromosome
Accession NZ_HG994850
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag LLO83_RS04755 Protein ID WP_000244765.1
Coordinates 975202..975609 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LLO83_RS04750 Protein ID WP_000354046.1
Coordinates 974955..975221 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO83_RS04730 (971043) 971043..972476 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
LLO83_RS04735 (972521) 972521..972832 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
LLO83_RS04740 (972996) 972996..973655 + 660 WP_000250274.1 hemolysin III family protein -
LLO83_RS04745 (973732) 973732..974712 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
LLO83_RS04750 (974955) 974955..975221 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LLO83_RS04755 (975202) 975202..975609 + 408 WP_000244765.1 protein YgfX Toxin
LLO83_RS04760 (975649) 975649..976170 - 522 WP_001055874.1 flavodoxin FldB -
LLO83_RS04765 (976282) 976282..977178 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LLO83_RS04770 (977203) 977203..977913 + 711 WP_000715229.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LLO83_RS04775 (977919) 977919..979652 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T285286 WP_000244765.1 NZ_HG994850:975202-975609 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT285286 WP_000354046.1 NZ_HG994850:974955-975221 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References