285280

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 1694482..1695829 Replicon chromosome
Accession NZ_HG992752
Organism Vibrio sp. B1FIG11 isolate LMG10946-nano

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag KHO06_RS24220 Protein ID WP_212582727.1
Coordinates 1694482..1695423 (-) Length 314 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A1B1NML2
Locus tag KHO06_RS24225 Protein ID WP_021018080.1
Coordinates 1695425..1695829 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHO06_RS24210 (ACOMICROBIO_LOCUS4377) 1691717..1692955 - 1239 WP_212582726.1 restriction endonuclease subunit S -
KHO06_RS24215 (ACOMICROBIO_LOCUS4378) 1692945..1694462 - 1518 WP_212583431.1 type I restriction-modification system subunit M -
KHO06_RS24220 (ACOMICROBIO_LMKGKHOH_03680) 1694482..1695423 - 942 WP_212582727.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KHO06_RS24225 (ACOMICROBIO_LMKGKHOH_03681) 1695425..1695829 - 405 WP_021018080.1 DUF6088 family protein Antitoxin
KHO06_RS24230 (ACOMICROBIO_LOCUS4379) 1696018..1696611 - 594 WP_085343577.1 tyrosine-type recombinase/integrase -
KHO06_RS24235 (ACOMICROBIO_LMKGKHOH_03683) 1696890..1697132 - 243 WP_012130179.1 helix-turn-helix domain-containing protein -
KHO06_RS24240 (ACOMICROBIO_LMKGKHOH_03684) 1697714..1698166 + 453 WP_244858422.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(37-300)

Antitoxin

Protein of unknown function DUF6088

(7-130)


Sequences

Toxin        


Download         Length: 314 a.a.        Molecular weight: 35747.18 Da        Isoelectric Point: 5.4766

>T285280 WP_212582727.1 NZ_HG992752:c1695423-1694482 [Vibrio sp. B1FIG11]
MNTLKQQFLEVSDALELGNPAIIEKDYWVVTLLAELAKVCPEHHQMVFSGGTALAKSNVKILRMSEDVDIKLIPNPAFDE
LSRAKKKAARKACVNEIEQALTQSGRFNVETRSVRDEYRYVEFELKYPQQFSQAPCLRPIIKLELIETIPLLDVESRSIQ
SLVAELYQQPQEVSAFDCVSIHATLVEKIISMLRRTMSVKRNTERSDDVALVRHIYDVHCITKLSMPELDSIDGLFKAVL
AEDIARFGNQHAEFVANPKQELQLGLKELEENAIFRQRFQDFVTPMVFNTEPHDFDTCFASFKRIAASLIEKI

Download         Length: 942 bp

>T285280 NZ_HG992752:c1695423-1694482 [Vibrio sp. B1FIG11]
ATGAATACACTAAAACAACAATTCCTTGAGGTTTCCGATGCGCTTGAGCTCGGAAACCCAGCCATCATTGAAAAAGATTA
CTGGGTCGTGACTTTACTGGCTGAGCTAGCGAAAGTTTGTCCTGAGCATCATCAAATGGTGTTTTCTGGCGGCACTGCGT
TGGCGAAATCAAACGTTAAAATTCTAAGAATGTCGGAAGATGTGGATATAAAACTCATCCCCAACCCAGCATTTGATGAA
CTGAGTCGAGCGAAAAAGAAAGCCGCGAGAAAGGCATGTGTTAACGAGATTGAACAGGCGCTCACCCAGTCAGGGCGATT
TAACGTTGAAACGCGTTCTGTGCGAGATGAGTACCGCTACGTCGAGTTTGAACTTAAATACCCGCAGCAGTTTAGTCAAG
CGCCCTGCCTGCGCCCCATCATCAAGTTAGAGTTAATCGAAACCATTCCATTACTGGATGTGGAGTCGCGCAGCATTCAA
TCTCTGGTAGCAGAGTTGTACCAACAACCACAAGAAGTGAGTGCATTTGATTGCGTCTCTATCCATGCCACATTGGTTGA
AAAAATTATTTCAATGCTGCGCCGTACCATGTCGGTAAAACGCAATACGGAGCGAAGCGATGATGTTGCTTTAGTTCGCC
ATATTTACGATGTTCACTGCATAACAAAGCTCTCAATGCCAGAACTCGACTCGATTGACGGCCTATTCAAAGCGGTATTG
GCAGAAGATATTGCCCGCTTTGGCAATCAACATGCCGAGTTTGTTGCCAACCCCAAACAAGAGCTACAACTTGGCCTTAA
AGAGCTTGAGGAAAATGCAATATTCCGCCAACGCTTTCAGGACTTTGTCACGCCAATGGTGTTTAACACCGAACCCCATG
ATTTTGATACCTGCTTTGCCTCATTTAAACGCATTGCAGCATCGCTAATTGAAAAAATTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15200.53 Da        Isoelectric Point: 10.5319

>AT285280 WP_021018080.1 NZ_HG992752:c1695829-1695425 [Vibrio sp. B1FIG11]
MTAADRIYQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVQQGELMKLGYGLYTKARINSLTGKPMPTNPGGTDALMRE
ILKMKGVDFEMDSLSLQSLSGTSTQIPSSIQYSWDPKQFNRKLVVGSRVLNLPS

Download         Length: 405 bp

>AT285280 NZ_HG992752:c1695829-1695425 [Vibrio sp. B1FIG11]
ATGACAGCAGCAGACCGCATTTATCAAAAGATAAAGCGTTCAAGACGTTATGTATTTGAACGCAAAGACTTTGATGGATT
TGCAAGTTACGACCAAATAGGTCGGGCCCTGAGGCAGCTTGTGCAGCAAGGTGAGTTAATGAAGCTTGGCTATGGCTTGT
ATACCAAAGCAAGAATCAATAGCCTCACTGGCAAGCCCATGCCGACTAATCCGGGAGGGACCGATGCCCTTATGCGAGAA
ATTCTTAAAATGAAAGGCGTTGATTTTGAGATGGATAGTCTATCGCTGCAAAGTCTTTCAGGCACGAGTACCCAAATTCC
ATCTTCTATTCAGTATTCATGGGACCCAAAACAGTTTAATCGCAAACTGGTGGTCGGTAGCCGTGTGCTGAACTTACCAA
GTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1NML2

References