285273

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1716632..1717148 Replicon chromosome
Accession NZ_HG992742
Organism Vibrio sp. B1ASS3

Toxin (Protein)


Gene name relB Uniprot ID A0A244CLX5
Locus tag KJB05_RS08090 Protein ID WP_069509627.1
Coordinates 1716879..1717148 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KJB05_RS08085 Protein ID WP_208446444.1
Coordinates 1716632..1716886 (+) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB05_RS08030 1711795..1711905 - 111 WP_017822022.1 DUF3265 domain-containing protein -
KJB05_RS08035 (ACOMICROBIO_NCLOACGD_01608) 1711902..1712261 - 360 WP_208446552.1 hypothetical protein -
KJB05_RS08040 (ACOMICROBIO_LOCUS1065) 1712465..1713999 + 1535 WP_208446524.1 IS3 family transposase -
KJB05_RS08045 (ACOMICROBIO_NCLOACGD_01611) 1714011..1714208 + 198 WP_208446447.1 hypothetical protein -
KJB05_RS28595 1714226..1714315 + 90 Protein_1525 DUF3265 domain-containing protein -
KJB05_RS08050 (ACOMICROBIO_NCLOACGD_01612) 1714345..1714644 + 300 WP_033006601.1 hypothetical protein -
KJB05_RS08055 1714674..1714763 + 90 WP_072615037.1 DUF3265 domain-containing protein -
KJB05_RS08060 (ACOMICROBIO_NCLOACGD_01613) 1714893..1715204 + 312 WP_213053110.1 hypothetical protein -
KJB05_RS08065 1715219..1715311 + 93 WP_075111289.1 DUF3265 domain-containing protein -
KJB05_RS08070 (ACOMICROBIO_NCLOACGD_01614) 1715337..1715846 + 510 WP_208446445.1 DUF4303 domain-containing protein -
KJB05_RS08075 1715869..1715961 + 93 WP_086375043.1 DUF3265 domain-containing protein -
KJB05_RS08080 (ACOMICROBIO_LOCUS1066) 1715993..1716304 + 312 WP_244142989.1 hypothetical protein -
KJB05_RS08085 (ACOMICROBIO_LOCUS1067) 1716632..1716886 + 255 WP_208446444.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KJB05_RS08090 (ACOMICROBIO_NCLOACGD_01617) 1716879..1717148 + 270 WP_069509627.1 Txe/YoeB family addiction module toxin Toxin
KJB05_RS08095 (ACOMICROBIO_NCLOACGD_01618) 1717410..1717721 + 312 WP_213053110.1 hypothetical protein -
KJB05_RS08100 1717736..1717828 + 93 WP_075111289.1 DUF3265 domain-containing protein -
KJB05_RS08105 1718304..1718396 + 93 WP_079866500.1 DUF3265 domain-containing protein -
KJB05_RS08110 (ACOMICROBIO_NCLOACGD_01620) 1718430..1718786 + 357 WP_208446443.1 hypothetical protein -
KJB05_RS08115 (ACOMICROBIO_NCLOACGD_01621) 1718789..1719970 + 1182 WP_191116413.1 PcfJ domain-containing protein -
KJB05_RS08120 (ACOMICROBIO_LOCUS1068) 1720113..1720517 + 405 WP_244868318.1 hydrolase -
KJB05_RS08125 (ACOMICROBIO_LOCUS1070) 1720551..1722085 + 1535 WP_208446524.1 IS3 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fos - 1630141..1726866 96725
- inside IScluster/Tn - - 1696123..1713999 17876
- flank IS/Tn - - 1721075..1722085 1010
- inside Integron - - 1714014..1726582 12568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-89)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 90 a.a.        Molecular weight: 10570.95 Da        Isoelectric Point: 8.8578

>T285273 WP_069509627.1 NZ_HG992742:1716879-1717148 [Vibrio sp. B1ASS3]
MSSSQRLLSWTDEAWGDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp


Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9439.58 Da        Isoelectric Point: 5.0623

>AT285273 WP_208446444.1 NZ_HG992742:1716632-1716886 [Vibrio sp. B1ASS3]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPKNAEHLNRSIAQYRAGNTTARE
LIDE

Download         Length: 255 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A244CLX5


Antitoxin

Source ID Structure

References