Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 2300251..2301019 Replicon chromosome
Accession NZ_HG969192
Organism Bartonella tribocorum strain BM1374166

Toxin (Protein)


Gene name VbhT Uniprot ID A9IYH2
Locus tag BM1374166_RS10270 Protein ID WP_012232419.1
Coordinates 2300251..2300844 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name VbhA Uniprot ID A9IYH4
Locus tag BM1374166_RS10275 Protein ID WP_012232420.1
Coordinates 2300831..2301019 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM1374166_RS10235 2295740..2296927 + 1188 WP_012232414.1 type IV secretion system protein VirB10 -
BM1374166_RS10240 2296991..2298043 + 1053 WP_038474261.1 P-type DNA transfer ATPase VirB11 -
BM1374166_RS10245 2298192..2298596 + 405 WP_012232416.1 EexN family lipoprotein -
BM1374166_RS10255 2298880..2299284 + 405 WP_012232417.1 EexN family lipoprotein -
BM1374166_RS10260 2299570..2299950 + 381 WP_012232418.1 EexN family lipoprotein -
BM1374166_RS10270 2300251..2300844 - 594 WP_012232419.1 Fic family protein Toxin
BM1374166_RS10275 2300831..2301019 - 189 WP_012232420.1 antitoxin VbhA family protein Antitoxin
BM1374166_RS10280 2301216..2301464 - 249 WP_012232421.1 HigA family addiction module antidote protein -
BM1374166_RS10285 2301508..2301778 - 271 Protein_1936 type II toxin-antitoxin system RelE/ParE family toxin -
BM1374166_RS13055 2301830..2301997 - 168 WP_158305317.1 hypothetical protein -
BM1374166_RS10295 2302258..2303619 - 1362 WP_012232423.1 phosphoglucosamine mutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(55-152)

Antitoxin

Antitoxin VbhA-like

(4-57)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 22606.42 Da        Isoelectric Point: 6.5008

>T285257 WP_012232419.1 NZ_HG969192:c2300844-2300251 [Bartonella tribocorum]
VEKYKGGGDPYTDPKTGVMYNRFEIQDKTALERVESTFAYVRSFELMRAATGGKFDLDHMKEIHRKLFGDVYEWAGEIRS
IDIAKGNSMFASYHQIESYTPKITQQLAKEQYLRGLDADEFSQRAGYYMGELNALHPFREGNGRTLREFMGQLAREAGYN
INWDGITREEMTKASIAAHFGNSEHLSVLIRQNLNLL

Download         Length: 594 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7181.31 Da        Isoelectric Point: 4.8409

>AT285257 WP_012232420.1 NZ_HG969192:c2301019-2300831 [Bartonella tribocorum]
MLSEDEIKRRRFAAKNALASQRLEGLEPDPKVVEQMERVIIGELETSDVIKDLMERIKRGEI

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9IYH2

Antitoxin

Source ID Structure
AlphaFold DB A9IYH4

References