285256

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 2250886..2251459 Replicon chromosome
Accession NZ_HG969192
Organism Bartonella tribocorum strain BM1374166

Toxin (Protein)


Gene name PumA Uniprot ID A0A5B9CX33
Locus tag BM1374166_RS09920 Protein ID WP_012232364.1
Coordinates 2250886..2251194 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B9CYS4
Locus tag BM1374166_RS09925 Protein ID WP_012232365.1
Coordinates 2251175..2251459 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM1374166_RS11925 2246046..2247341 - 1296 WP_012232359.1 hypothetical protein -
BM1374166_RS09900 2247376..2248227 - 852 WP_012232360.1 hypothetical protein -
BM1374166_RS09905 2248229..2248654 - 426 WP_012232361.1 hypothetical protein -
BM1374166_RS09910 2248654..2250111 - 1458 WP_012232362.1 hypothetical protein -
BM1374166_RS09915 2250113..2250820 - 708 WP_012232363.1 hypothetical protein -
BM1374166_RS09920 2250886..2251194 + 309 WP_012232364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BM1374166_RS09925 2251175..2251459 + 285 WP_012232365.1 putative addiction module antidote protein Antitoxin
BM1374166_RS09930 2251495..2251875 - 381 WP_012232366.1 hypothetical protein -
BM1374166_RS09935 2251886..2252266 - 381 WP_012232367.1 hypothetical protein -
BM1374166_RS09940 2252289..2253416 - 1128 WP_012232368.1 N4-gp56 family major capsid protein -
BM1374166_RS09945 2253510..2254397 - 888 WP_012232369.1 hypothetical protein -
BM1374166_RS09950 2254411..2256429 - 2019 WP_012232370.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2227959..2281718 53759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11876.83 Da        Isoelectric Point: 9.9055

>T285256 WP_012232364.1 NZ_HG969192:2250886-2251194 [Bartonella tribocorum]
MIFIHKTIEFDNWLKKLKDKKAKAIILQRVVRLKQGLLGDVKFFNSIGEVRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10329.73 Da        Isoelectric Point: 7.0111

>AT285256 WP_012232365.1 NZ_HG969192:2251175-2251459 [Bartonella tribocorum]
MKTTPFKPEEYLEDIEVQQAFLNEAFKTGDAAHIADAIGIVARSQNMRALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLFVQSSTS

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B9CX33

Antitoxin

Source ID Structure
AlphaFold DB A0A5B9CYS4

References