Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 1159844..1160417 Replicon chromosome
Accession NZ_HG969192
Organism Bartonella tribocorum strain BM1374166

Toxin (Protein)


Gene name PumA Uniprot ID A0A5B9CX33
Locus tag BM1374166_RS05075 Protein ID WP_012232364.1
Coordinates 1160109..1160417 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B9CYS4
Locus tag BM1374166_RS05070 Protein ID WP_012232365.1
Coordinates 1159844..1160128 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM1374166_RS05035 1155071..1156558 - 1488 WP_038473542.1 DUF3987 domain-containing protein -
BM1374166_RS12835 1156530..1156679 - 150 WP_169309787.1 hypothetical protein -
BM1374166_RS12530 1156816..1156887 - 72 Protein_962 virulence-associated protein E -
BM1374166_RS05045 1156986..1157186 - 201 WP_007347430.1 DNA-binding protein -
BM1374166_RS05050 1157395..1158561 - 1167 WP_012231670.1 site-specific integrase -
BM1374166_RS05055 1158724..1159014 + 291 Protein_965 DUF4043 family protein -
BM1374166_RS05060 1159037..1159417 + 381 WP_012232367.1 hypothetical protein -
BM1374166_RS05065 1159428..1159808 + 381 WP_012232366.1 hypothetical protein -
BM1374166_RS05070 1159844..1160128 - 285 WP_012232365.1 putative addiction module antidote protein Antitoxin
BM1374166_RS05075 1160109..1160417 - 309 WP_012232364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BM1374166_RS05080 1160483..1161190 + 708 WP_012232363.1 hypothetical protein -
BM1374166_RS05085 1161192..1162649 + 1458 WP_012231677.1 hypothetical protein -
BM1374166_RS05090 1162649..1163074 + 426 WP_012231678.1 hypothetical protein -
BM1374166_RS05095 1163076..1163999 + 924 WP_012231679.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1013501..1192685 179184


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11876.83 Da        Isoelectric Point: 9.9055

>T285254 WP_012232364.1 NZ_HG969192:c1160417-1160109 [Bartonella tribocorum]
MIFIHKTIEFDNWLKKLKDKKAKAIILQRVVRLKQGLLGDVKFFNSIGEVRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10329.73 Da        Isoelectric Point: 7.0111

>AT285254 WP_012232365.1 NZ_HG969192:c1160128-1159844 [Bartonella tribocorum]
MKTTPFKPEEYLEDIEVQQAFLNEAFKTGDAAHIADAIGIVARSQNMRALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLFVQSSTS

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B9CX33

Antitoxin

Source ID Structure
AlphaFold DB A0A5B9CYS4

References