285250

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 547929..548482 Replicon chromosome
Accession NZ_HG969192
Organism Bartonella tribocorum strain BM1374166

Toxin (Protein)


Gene name brnT Uniprot ID A9IPT5
Locus tag BM1374166_RS02400 Protein ID WP_012231069.1
Coordinates 548234..548482 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A9IPT2
Locus tag BM1374166_RS02395 Protein ID WP_012231068.1
Coordinates 547929..548237 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM1374166_RS02355 543455..544561 - 1107 WP_012230791.1 hypothetical protein -
BM1374166_RS02360 544561..545388 - 828 WP_012230798.1 baseplate J/gp47 family protein -
BM1374166_RS02365 545385..545726 - 342 WP_038473244.1 GPW/gp25 family protein -
BM1374166_RS02370 545723..546388 - 666 WP_012231064.1 phage baseplate assembly protein V -
BM1374166_RS02375 546369..546911 - 543 WP_012230801.1 hypothetical protein -
BM1374166_RS02380 546961..547233 + 273 WP_012231065.1 toxin HicA -
BM1374166_RS02385 547223..547540 + 318 WP_012231066.1 type II toxin-antitoxin system HicB family antitoxin -
BM1374166_RS02390 547586..547858 + 273 WP_012231067.1 BrnA antitoxin family protein -
BM1374166_RS02395 547929..548237 - 309 WP_012231068.1 BrnA antitoxin family protein Antitoxin
BM1374166_RS02400 548234..548482 - 249 WP_012231069.1 BrnT family toxin Toxin
BM1374166_RS02405 548577..548933 - 357 WP_012231070.1 hypothetical protein -
BM1374166_RS02410 548935..550011 - 1077 WP_012231071.1 major capsid protein -
BM1374166_RS02415 550024..550392 - 369 WP_012230814.1 head decoration protein -
BM1374166_RS02420 550389..550733 - 345 WP_038474435.1 hypothetical protein -
BM1374166_RS02425 550652..551719 - 1068 WP_038473315.1 S49 family peptidase -
BM1374166_RS02430 551709..553280 - 1572 WP_012230821.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 477153..595130 117977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-77)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-100)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9351.99 Da        Isoelectric Point: 8.6593

>T285250 WP_012231069.1 NZ_HG969192:c548482-548234 [Bartonella tribocorum]
MIITYDEIKRHKNIEKHGLDFADLQIEFFETAIILPAKQGRFMAINVFTNNVIAVVFATLGDEAVSIISMRRASKKERSL
IL

Download         Length: 249 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11524.11 Da        Isoelectric Point: 4.9534

>AT285250 WP_012231068.1 NZ_HG969192:c548237-547929 [Bartonella tribocorum]
MTKYPYIKPLTDEEEAEIQKEIAYDPDAPEATDEQIAQAKSFAEVFPDLAESIKRSRGRPQIDNPKEQVSIRLSPDVLKK
LKALGRGWQSKVDDILRKAVGL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9IPT5

Antitoxin

Source ID Structure
AlphaFold DB A9IPT2

References