Detailed information of TA system TA028525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazE-MazF
• Location: 3813382..3813962
• Replicon: chromosome
• Accession: NC_019695
• Organism: Chroococcidiopsis thermalis PCC 7203

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: K9U3S3
• Locus tag: CHRO_RS16765
• Protein ID: WP_015155424.1
• Coordinates: 3813382..3813642 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: CHRO_RS16770
• Protein ID: WP_015155425.1
• Coordinates: 3813636..3813962 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHRO_RS16735	3808534..3809277	+	744	WP_015155418.1	phycobilisome rod-core linker polypeptide	-
CHRO_RS16740	3809498..3810259	+	762	WP_015155419.1	phycobilisome rod-core linker polypeptide	-
CHRO_RS16745	3810487..3810960	+	474	WP_015155420.1	hypothetical protein	-
CHRO_RS16750	3811074..3811946	-	873	WP_015155421.1	NAD(P)-dependent oxidoreductase	-
CHRO_RS16755	3812238..3812645	+	408	WP_015155422.1	50S ribosomal protein L21	-
CHRO_RS16760	3812742..3813029	+	288	WP_015155423.1	50S ribosomal protein L27	-
CHRO_RS16765	3813382..3813642	+	261	WP_015155424.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Toxin
CHRO_RS16770	3813636..3813962	+	327	WP_015155425.1	type II toxin-antitoxin system PemK/MazF family toxin	Antitoxin
CHRO_RS16775	3813965..3814939	+	975	WP_015155426.1	XdhC family protein	-
CHRO_RS16780	3814984..3815946	-	963	WP_015155427.1	hypothetical protein	-
CHRO_RS16785	3816155..3816721	+	567	WP_015155428.1	hypothetical protein	-
CHRO_RS16790	3816732..3817268	-	537	WP_015155429.1	bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR	-
CHRO_RS16795	3817371..3818657	-	1287	WP_015155430.1	aminopeptidase P N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• SpoVT-AbrB domain (10-45)

Antitoxin

• mRNA interferase PemK-like (1-105)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9841.17 Da
• Isoelectric Point: 4.4992

>T28525 WP_015155424.1 NC_019695:3813382-3813642 [Chroococcidiopsis thermalis PCC 7203]
MGTGIRTRIVRIGNSQGIRIPKPLLEQSGIDTEVEIEVQDECLIVRAASRSRIGWDKAFAAMAEQKDDVLLDDVNITEWD
RTEWKW

Nucleotide

• Length: 261 bp

>T28525 NC_019695:3813382-3813642 [Chroococcidiopsis thermalis PCC 7203]
ATGGGTACGGGTATCAGAACTCGCATTGTCAGAATTGGTAATTCTCAAGGCATCCGCATTCCTAAACCACTATTGGAGCA
AAGTGGTATTGATACAGAAGTAGAGATTGAAGTTCAAGACGAGTGCTTAATTGTGCGTGCAGCATCGCGATCGCGTATCG
GCTGGGATAAAGCATTTGCTGCAATGGCAGAACAAAAAGATGATGTTTTACTTGATGATGTCAATATAACAGAGTGGGAT
CGGACTGAGTGGAAATGGTAG

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12127.23 Da
• Isoelectric Point: 9.1569

>AT28525 WP_015155425.1 NC_019695:3813636-3813962 [Chroococcidiopsis thermalis PCC 7203]
MVVKRFDVFLINLHPPTVGSEIQKTRPCVIVSPNEMNQYIATVIVAPMTTKGQPYPTRIACQFQGKDGQIVLDQIRTVDK
TRLVKKLGQINSNEQKAVLDILAEMFAE

Nucleotide

• Length: 327 bp

>AT28525 NC_019695:3813636-3813962 [Chroococcidiopsis thermalis PCC 7203]
ATGGTAGTTAAGCGTTTTGATGTGTTTCTGATTAACCTCCATCCTCCCACAGTTGGTAGTGAAATTCAAAAAACAAGACC
GTGCGTCATCGTCTCACCAAATGAAATGAATCAGTACATTGCCACTGTTATCGTTGCGCCGATGACAACAAAAGGTCAGC
CGTATCCTACAAGGATCGCTTGCCAGTTTCAAGGTAAAGATGGGCAGATCGTTTTAGACCAAATTCGCACTGTTGATAAA
ACTCGATTGGTCAAAAAACTCGGTCAAATCAATTCCAACGAACAAAAAGCTGTTTTGGATATCCTCGCCGAAATGTTTGC
AGAGTAA

Structures

Toxin

• AlphaFold DB: K9U3S3