285249

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 491228..491708 Replicon chromosome
Accession NZ_HG969192
Organism Bartonella tribocorum strain BM1374166

Toxin (Protein)


Gene name pasB Uniprot ID A9IPB3
Locus tag BM1374166_RS02070 Protein ID WP_012230995.1
Coordinates 491439..491708 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID N6VJG4
Locus tag BM1374166_RS02065 Protein ID WP_007346764.1
Coordinates 491228..491455 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM1374166_RS02020 486569..486775 + 207 WP_038474459.1 hypothetical protein -
BM1374166_RS11830 487067..488465 + 1399 Protein_384 AAA family ATPase -
BM1374166_RS02035 488614..488937 - 324 WP_038473287.1 type II toxin-antitoxin system PemK/MazF family toxin -
BM1374166_RS02040 488937..489161 - 225 WP_012230987.1 antitoxin MazE family protein -
BM1374166_RS02045 489384..489830 + 447 WP_012230988.1 single-stranded DNA-binding protein -
BM1374166_RS02050 489884..490384 + 501 WP_012230989.1 hypothetical protein -
BM1374166_RS02055 490437..490694 + 258 WP_012230990.1 antitoxin -
BM1374166_RS02060 490691..491017 + 327 WP_012230991.1 type II toxin-antitoxin system PemK/MazF family toxin -
BM1374166_RS02065 491228..491455 + 228 WP_007346764.1 ribbon-helix-helix protein, CopG family Antitoxin
BM1374166_RS02070 491439..491708 + 270 WP_012230995.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BM1374166_RS02080 492257..492700 - 444 WP_012231000.1 hypothetical protein -
BM1374166_RS02090 494847..495371 - 525 WP_081458153.1 hypothetical protein -
BM1374166_RS02095 495506..496084 - 579 WP_038473291.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 477153..595130 117977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(2-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10460.48 Da        Isoelectric Point: 10.4255

>T285249 WP_012230995.1 NZ_HG969192:491439-491708 [Bartonella tribocorum]
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQLSGLWRYRVGDYRILCELYDKKLVVLVLAV
GHRKNIYKG

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8742.78 Da        Isoelectric Point: 4.8780

>AT285249 WP_007346764.1 NZ_HG969192:491228-491455 [Bartonella tribocorum]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9IPB3

Antitoxin

Source ID Structure
AlphaFold DB N6VJG4

References