Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3779273..3779835 Replicon chromosome
Accession NC_019695
Organism Chroococcidiopsis thermalis PCC 7203

Toxin (Protein)


Gene name mazF Uniprot ID K9U349
Locus tag CHRO_RS16580 Protein ID WP_015155386.1
Coordinates 3779503..3779835 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID K9U1Z6
Locus tag CHRO_RS16575 Protein ID WP_015155385.1
Coordinates 3779273..3779509 (+) Length 79 a.a.

Genomic Context

CHRO_RS16530CHRO_RS16535CHRO_RS29725CHRO_RS16565CHRO_RS16575CHRO_RS16580CHRO_RS16585CHRO_RS16590CHRO_RS16595CHRO_RS16605CHRO_RS16545CHRO_RS16550CHRO_RS16555CHRO_RS16570CHRO_RS16600
Location: 3774446..3774637 (192 bp)
Type: Others
Protein ID: WP_015155377.1
Location: 3774637..3775572 (936 bp)
Type: Others
Protein ID: WP_181824373.1
Location: 3777782..3777961 (180 bp)
Type: Others
Protein ID: WP_051033245.1
Location: 3778115..3778309 (195 bp)
Type: Others
Protein ID: WP_015155383.1
Location: 3779273..3779509 (237 bp)
Type: Antitoxin
Protein ID: WP_015155385.1
Location: 3779503..3779835 (333 bp)
Type: Toxin
Protein ID: WP_015155386.1
Location: 3779893..3780105 (213 bp)
Type: Others
Protein ID: WP_015155387.1
Location: 3780092..3780493 (402 bp)
Type: Others
Protein ID: WP_015155388.1
Location: 3780562..3781536 (975 bp)
Type: Others
Protein ID: WP_015155389.1
Location: 3783162..3783746 (585 bp)
Type: Others
Protein ID: WP_015155391.1
Location: 3776104..3776712 (609 bp)
Type: Others
Protein ID: WP_041463216.1
Location: 3776812..3777237 (426 bp)
Type: Others
Protein ID: WP_015155381.1
Location: 3777234..3777494 (261 bp)
Type: Others
Protein ID: WP_015155382.1
Location: 3778287..3779192 (906 bp)
Type: Others
Protein ID: WP_015155384.1
Location: 3781612..3782763 (1152 bp)
Type: Others
Protein ID: WP_015155390.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CHRO_RS165303774446..3774637+192WP_015155377.1hypothetical protein-
CHRO_RS165353774637..3775572+936WP_181824373.1cobalt-precorrin-6A reductase-
CHRO_RS165453776104..3776712-609WP_041463216.12OG-Fe(II) oxygenase-
CHRO_RS165503776812..3777237-426WP_015155381.1PIN domain-containing protein-
CHRO_RS165553777234..3777494-261WP_015155382.1hypothetical protein-
CHRO_RS297253777782..3777961+180WP_051033245.1hypothetical protein-
CHRO_RS165653778115..3778309+195WP_015155383.1heavy-metal-associated domain-containing protein-
CHRO_RS165703778287..3779192-906WP_015155384.1alpha/beta hydrolase-
CHRO_RS165753779273..3779509+237WP_015155385.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
CHRO_RS165803779503..3779835+333WP_015155386.1type II toxin-antitoxin system PemK/MazF family toxinToxin
CHRO_RS165853779893..3780105+213WP_015155387.1type II toxin-antitoxin system VapB family antitoxin-
CHRO_RS165903780092..3780493+402WP_015155388.1PIN domain nuclease-
CHRO_RS165953780562..3781536+975WP_015155389.1tyrosine-type recombinase/integrase-
CHRO_RS166003781612..3782763-1152WP_015155390.1tyrosine-type recombinase/integrase-
CHRO_RS166053783162..3783746+585WP_015155391.1DUF99 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-108)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12562.72 Da        Isoelectric Point: 9.3549

>T28524 WP_015155386.1 NC_019695:3779503-3779835 [Chroococcidiopsis thermalis PCC 7203]
VVEVPARGTFIWLNFEPQSGREQMGRRPALVVSHTAFNRKRGFAFVCPISNTRRKNPFYIAIPEGLAVTGVIMCDQLRSL
DYRIRNAEFLGECPISLLEEVLLRIQPIFL

Download         Length: 333 bp

>T28524 NC_019695:3779503-3779835 [Chroococcidiopsis thermalis PCC 7203]
GTGGTAGAAGTTCCAGCGCGAGGTACTTTCATTTGGCTGAATTTTGAACCGCAATCTGGACGCGAACAAATGGGTAGAAG
ACCTGCTTTAGTTGTTAGCCATACAGCTTTTAACCGCAAGCGTGGTTTTGCGTTCGTTTGTCCCATCAGTAATACTAGGC
GGAAAAATCCTTTTTATATTGCGATTCCAGAAGGTTTAGCTGTAACTGGAGTCATCATGTGCGACCAATTGCGATCGCTA
GATTACCGCATCAGAAATGCAGAGTTTTTAGGTGAATGTCCTATTTCCCTACTAGAAGAAGTCTTACTCCGAATTCAACC
GATCTTCTTGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9121.44 Da        Isoelectric Point: 4.9155

>AT28524 WP_015155385.1 NC_019695:3779273-3779509 [Chroococcidiopsis thermalis PCC 7203]
MRSSIGKWGNSLGLRIPRHIVEELSLHPNDEVECRVEKGRLIVEVVHKRKYTLEELLSQEMEPEPEIDWGKPMGEEAW

Download         Length: 237 bp

>AT28524 NC_019695:3779273-3779509 [Chroococcidiopsis thermalis PCC 7203]
ATGCGAAGTTCAATCGGTAAATGGGGAAATTCGCTGGGATTGAGGATACCCAGACATATTGTAGAAGAATTATCTCTGCA
TCCAAATGATGAAGTTGAGTGTCGCGTTGAAAAAGGTAGATTGATTGTTGAGGTCGTACACAAGCGCAAATACACCTTAG
AGGAATTGCTTTCTCAAGAGATGGAACCCGAACCAGAAATCGACTGGGGTAAACCTATGGGTGAAGAAGCGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBK9U349

Antitoxin

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Source
ID
Structure
AlphaFold DBK9U1Z6

References