Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE-RHH
Location 892187..892746 Replicon chromosome
Accession NZ_HG969191
Organism Bartonella henselae strain BM1374165

Toxin (Protein)


Gene name relE Uniprot ID X5M706
Locus tag BM1374165_RS03835 Protein ID WP_011180615.1
Coordinates 892187..892459 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID X5M4C9
Locus tag BM1374165_RS03840 Protein ID WP_038487495.1
Coordinates 892456..892746 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM1374165_RS08610 887437..887802 + 366 Protein_726 hypothetical protein -
BM1374165_RS03795 887902..888267 + 366 WP_038488832.1 hypothetical protein -
BM1374165_RS03800 888285..889052 - 768 WP_038488829.1 hypothetical protein -
BM1374165_RS03805 889183..889665 + 483 WP_038487489.1 phage related protein -
BM1374165_RS03810 889655..889999 + 345 WP_034452646.1 DUF1376 domain-containing protein -
BM1374165_RS03815 889989..891128 + 1140 WP_038487492.1 DUF1376 domain-containing protein -
BM1374165_RS08925 891112..891498 + 387 WP_082246570.1 hypothetical protein -
BM1374165_RS03830 891680..892182 + 503 Protein_733 hypothetical protein -
BM1374165_RS03835 892187..892459 - 273 WP_011180615.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BM1374165_RS03840 892456..892746 - 291 WP_038487495.1 hypothetical protein Antitoxin
BM1374165_RS03845 892968..893414 + 447 WP_038487497.1 single-stranded DNA-binding protein -
BM1374165_RS03850 893470..893982 + 513 WP_172642310.1 hypothetical protein -
BM1374165_RS03855 894063..894320 + 258 WP_038487501.1 antitoxin -
BM1374165_RS03860 894320..894652 + 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin -
BM1374165_RS03865 894760..894987 + 228 WP_007346764.1 ribbon-helix-helix protein, CopG family -
BM1374165_RS03870 894971..895240 + 270 WP_038487435.1 type II toxin-antitoxin system RelE/ParE family toxin -
BM1374165_RS03875 895270..895704 - 435 WP_038487438.1 hypothetical protein -
BM1374165_RS03880 895777..896250 - 474 Protein_743 hypothetical protein -
BM1374165_RS03885 896551..896877 + 327 WP_051524333.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 859596..897763 38167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10747.75 Da        Isoelectric Point: 11.3976

>T285236 WP_011180615.1 NZ_HG969191:c892459-892187 [Bartonella henselae]
MKLVWTRIAHYDRQKIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP

Download         Length: 273 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11155.54 Da        Isoelectric Point: 4.7370

>AT285236 WP_038487495.1 NZ_HG969191:c892746-892456 [Bartonella henselae]
MAETTFTFRVDDVLKSEFSRAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVQLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067W4L5

Antitoxin

Source ID Structure
AlphaFold DB X5M4C9

References