Detailed information of TA system TA028523

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 88306..88742
• Replicon: chromosome
• Accession: NC_019695
• Organism: Chroococcidiopsis thermalis PCC 7203

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CHRO_RS00360
• Protein ID: WP_015152183.1
• Coordinates: 88518..88742 (+)
• Length: 75 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CHRO_RS00355
• Protein ID: WP_015152182.1
• Coordinates: 88306..88518 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHRO_RS00335	84241..85302	+	1062	WP_015152178.1	tRNA 2-thiouridine(34) synthase MnmA	-
CHRO_RS00340	85411..87201	-	1791	WP_015152179.1	translational GTPase TypA	-
CHRO_RS00345	87300..87773	-	474	WP_015152180.1	hypothetical protein	-
CHRO_RS00350	87939..88160	+	222	WP_015152181.1	helix-turn-helix domain-containing protein	-
CHRO_RS00355	88306..88518	+	213	WP_015152182.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CHRO_RS00360	88518..88742	+	225	WP_015152183.1	type II toxin-antitoxin system HicA family toxin	Toxin
CHRO_RS00365	88748..89323	+	576	WP_015152184.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-
CHRO_RS00370	89392..90495	+	1104	WP_015152185.1	ABC transporter ATP-binding protein	-
CHRO_RS00375	90617..92485	-	1869	WP_015152186.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (9-64)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (7-68)

Sequences

Toxin

Protein

• Length: 75 a.a.
• Molecular weight: 8314.84 Da
• Isoelectric Point: 10.8073

>T28523 WP_015152183.1 NC_019695:88518-88742 [Chroococcidiopsis thermalis PCC 7203]
IPKVPAVTGSEVIHALEKVGFQVVRQKGIYVRMQHEDGRVVTIPVHAGKNVGRGLLRKILRDAKMTREEFIDLL

Nucleotide

• Length: 225 bp

>T28523 NC_019695:88518-88742 [Chroococcidiopsis thermalis PCC 7203]
ATACCAAAAGTACCTGCTGTTACAGGCAGTGAAGTTATTCATGCTCTTGAGAAAGTGGGCTTTCAAGTAGTTCGACAAAA
GGGTATTTATGTCAGAATGCAGCATGAAGACGGAAGAGTAGTGACGATTCCCGTTCATGCTGGTAAAAATGTCGGCAGAG
GTTTACTACGTAAAATCTTACGTGATGCCAAGATGACAAGAGAAGAGTTTATAGACCTGCTTTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 8192.22 Da
• Isoelectric Point: 3.8403

>AT28523 WP_015152182.1 NC_019695:88306-88518 [Chroococcidiopsis thermalis PCC 7203]
MNNTKEFYVIIERDEDGYYVGEVPQLKACYSQSETIDELIANIKEVIELCLEEEEYENLPEFVGIQKVVK

Nucleotide

• Length: 213 bp

>AT28523 NC_019695:88306-88518 [Chroococcidiopsis thermalis PCC 7203]
ATGAATAATACTAAAGAATTTTACGTTATCATTGAACGGGATGAAGATGGATATTATGTAGGAGAAGTTCCTCAGCTTAA
AGCCTGTTACAGCCAAAGCGAAACTATTGACGAGCTAATAGCAAATATTAAAGAAGTCATCGAACTTTGTTTGGAAGAAG
AGGAGTACGAAAACTTACCGGAGTTTGTAGGTATCCAAAAGGTAGTAAAATAA