285217

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 117011..117570 Replicon plasmid pEC958
Accession NZ_HG941719
Organism Escherichia coli O25b:H4-ST131 strain EC958

Toxin (Protein)


Gene name relE Uniprot ID V0SVC8
Locus tag EC958_RS26270 Protein ID WP_000421272.1
Coordinates 117295..117570 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SRR3
Locus tag EC958_RS26265 Protein ID WP_001387467.1
Coordinates 117011..117295 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC958_RS26240 112286..112891 - 606 WP_000509965.1 recombinase family protein -
EC958_RS26245 112986..113687 + 702 Protein_127 DUF4158 domain-containing protein -
EC958_RS26250 113739..114443 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
EC958_RS29665 114506..114610 + 105 Protein_129 RidA family protein -
EC958_RS26255 114643..115608 + 966 WP_001022265.1 2-keto-3-deoxygluconate transporter -
EC958_RS26260 115654..116406 - 753 WP_000562172.1 IclR family transcriptional regulator -
EC958_RS26265 117011..117295 + 285 WP_001387467.1 ribbon-helix-helix domain-containing protein Antitoxin
EC958_RS26270 117295..117570 + 276 WP_000421272.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EC958_RS26275 117676..117969 + 294 WP_001105060.1 hypothetical protein -
EC958_RS29495 118004..118132 - 129 Protein_135 IS481 family transposase -
EC958_RS26280 118165..119334 - 1170 WP_001072355.1 hypothetical protein -
EC958_RS26290 119827..120134 + 308 Protein_137 type II toxin-antitoxin system ParD family antitoxin -
EC958_RS26295 120423..121120 + 698 Protein_138 IS1 family transposase -
EC958_RS26300 121374..122396 - 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / aadA5 / qacE / sul1 / mph(A) / blaCTX-M-15 / blaOXA-1 / aac(6')-Ib-cr / tet(A) - 1..135602 135602
- flank IS/Tn - - 120617..121120 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 10.0871

>T285217 WP_000421272.1 NZ_HG941719:117295-117570 [Escherichia coli O25b:H4-ST131]
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10460.87 Da        Isoelectric Point: 5.6558

>AT285217 WP_001387467.1 NZ_HG941719:117011-117295 [Escherichia coli O25b:H4-ST131]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SVC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y880

References