285205

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3888265..3889065 Replicon chromosome
Accession NZ_HG941718
Organism Escherichia coli O25b:H4-ST131 strain EC958

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag EC958_RS19625 Protein ID WP_000342452.1
Coordinates 3888265..3888792 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag EC958_RS19630 Protein ID WP_001277107.1
Coordinates 3888799..3889065 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC958_RS19600 3883341..3884108 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
EC958_RS19605 3884105..3885382 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
EC958_RS19610 3885379..3886305 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
EC958_RS19615 3886353..3887462 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
EC958_RS19620 3887885..3888268 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
EC958_RS19625 3888265..3888792 - 528 WP_000342452.1 GNAT family N-acetyltransferase Toxin
EC958_RS19630 3888799..3889065 - 267 WP_001277107.1 DUF1778 domain-containing protein Antitoxin
EC958_RS19635 3889214..3890317 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
EC958_RS19640 3890588..3891442 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
EC958_RS19645 3891687..3892745 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
EC958_RS19650 3892738..3893406 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T285205 WP_000342452.1 NZ_HG941718:c3888792-3888265 [Escherichia coli O25b:H4-ST131]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT285205 WP_001277107.1 NZ_HG941718:c3889065-3888799 [Escherichia coli O25b:H4-ST131]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References