Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 3358349..3359630 Replicon chromosome
Accession NZ_HG941718
Organism Escherichia coli O25b:H4-ST131 strain EC958

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1X3JHM4
Locus tag EC958_RS16940 Protein ID WP_001114681.1
Coordinates 3358737..3359630 (+) Length 298 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID V0YCI1
Locus tag EC958_RS16935 Protein ID WP_000208383.1
Coordinates 3358349..3358744 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC958_RS16890 3353843..3354328 + 486 WP_000849566.1 antirestriction protein -
EC958_RS16895 3354344..3354820 + 477 WP_001186726.1 RadC family protein -
EC958_RS16900 3354883..3355104 + 222 WP_000692329.1 DUF987 domain-containing protein -
EC958_RS16905 3355123..3355767 + 645 WP_000094916.1 hypothetical protein -
EC958_RS16910 3355817..3356197 + 381 WP_001285598.1 type IV toxin-antitoxin system YeeU family antitoxin -
EC958_RS16915 3356274..3356651 + 378 WP_000854689.1 TA system toxin CbtA family protein -
EC958_RS16920 3356648..3357136 + 489 WP_000761699.1 hypothetical protein -
EC958_RS16925 3357153..3357350 + 198 WP_000839293.1 DUF957 domain-containing protein -
EC958_RS16930 3357435..3358280 + 846 WP_023281696.1 DUF4942 domain-containing protein -
EC958_RS16935 3358349..3358744 + 396 WP_000208383.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
EC958_RS16940 3358737..3359630 + 894 WP_001114681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
EC958_RS16945 3360101..3360271 + 171 Protein_3224 IS110 family transposase -
EC958_RS16950 3360620..3362119 + 1500 WP_000174401.1 IS21-like element ISEc10 family transposase -
EC958_RS16955 3362116..3362871 + 756 Protein_3226 IS21-like element ISEc10 family helper ATPase IstB -
EC958_RS16960 3363497..3364480 + 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-292)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 34298.40 Da        Isoelectric Point: 5.9850

>T285202 WP_001114681.1 NZ_HG941718:3358737-3359630 [Escherichia coli O25b:H4-ST131]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN

Download         Length: 894 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14608.03 Da        Isoelectric Point: 11.3150

>AT285202 WP_000208383.1 NZ_HG941718:3358349-3358744 [Escherichia coli O25b:H4-ST131]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3JHM4

Antitoxin

Source ID Structure
AlphaFold DB V0YCI1

References