Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3212021..3212675 Replicon chromosome
Accession NZ_HG941718
Organism Escherichia coli O25b:H4-ST131 strain EC958

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag EC958_RS16120 Protein ID WP_000244765.1
Coordinates 3212021..3212428 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag EC958_RS16125 Protein ID WP_000354050.1
Coordinates 3212409..3212675 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC958_RS16100 3207978..3209711 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
EC958_RS16105 3209717..3210427 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EC958_RS16110 3210452..3211348 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
EC958_RS16115 3211460..3211981 + 522 WP_001055874.1 flavodoxin FldB -
EC958_RS16120 3212021..3212428 - 408 WP_000244765.1 protein YgfX Toxin
EC958_RS16125 3212409..3212675 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
EC958_RS16130 3212918..3213898 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
EC958_RS16135 3213975..3214634 - 660 WP_000250275.1 hemolysin III family protein -
EC958_RS16140 3214798..3215109 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
EC958_RS16145 3215154..3216587 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T285200 WP_000244765.1 NZ_HG941718:c3212428-3212021 [Escherichia coli O25b:H4-ST131]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT285200 WP_000354050.1 NZ_HG941718:c3212675-3212409 [Escherichia coli O25b:H4-ST131]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References