Detailed information of TA system TA028520

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 4521970..4522564
• Replicon: chromosome
• Accession: NC_019693
• Organism: Oscillatoria acuminata PCC 6304

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K9TKT8
• Locus tag: OSCIL6304_RS17705
• Protein ID: WP_015149783.1
• Coordinates: 4522208..4522564 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: K9TMA9
• Locus tag: OSCIL6304_RS17700
• Protein ID: WP_015149782.1
• Coordinates: 4521970..4522215 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OSCIL6304_RS33245	4517546..4518850	+	1305	WP_156824070.1	tetratricopeptide repeat protein	-
OSCIL6304_RS17680	4518974..4519303	+	330	WP_015149779.1	hypothetical protein	-
OSCIL6304_RS17685	4519417..4520007	+	591	WP_015149780.1	AAA family ATPase	-
OSCIL6304_RS17690	4520004..4520198	+	195	WP_015149781.1	hypothetical protein	-
OSCIL6304_RS17695	4520493..4521944	+	1452	WP_015149066.1	IS66 family transposase	-
OSCIL6304_RS17700	4521970..4522215	+	246	WP_015149782.1	hypothetical protein	Antitoxin
OSCIL6304_RS17705	4522208..4522564	+	357	WP_015149783.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OSCIL6304_RS17710	4523158..4524423	+	1266	WP_015149784.1	GUN4 domain-containing protein	-
OSCIL6304_RS17715	4524660..4526567	-	1908	WP_015149785.1	glutamine--fructose-6-phosphate transaminase (isomerizing)	-
OSCIL6304_RS32505	4526898..4527143	-	246	WP_007355303.1	photosystem I iron-sulfur center protein PsaC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-99)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13873.84 Da
• Isoelectric Point: 6.4102

>T28520 WP_015149783.1 NC_019693:4522208-4522564 [Oscillatoria acuminata PCC 6304]
MNNIPISVRFADEFERRLYRLSKKYRSIRQDVEPILEQLQQKILLGDRLSGFGSNLYVYKVRAKNSNIQKGKSGGYRIIY
LLESETSILLLTIYSKSEQEDMTTEQIQTILEELYESE

Nucleotide

• Length: 357 bp

>T28520 NC_019693:4522208-4522564 [Oscillatoria acuminata PCC 6304]
ATGAATAATATACCAATTTCGGTGAGATTTGCCGATGAATTTGAAAGAAGATTATATCGGCTCTCCAAAAAATACCGGAG
TATTCGACAGGATGTTGAGCCGATTCTTGAACAACTCCAGCAAAAAATACTATTAGGCGATCGGCTTTCTGGTTTTGGCT
CTAACCTTTATGTTTACAAGGTTAGAGCCAAAAATAGTAATATCCAGAAAGGAAAAAGTGGCGGCTATCGCATTATTTAT
TTGCTCGAATCAGAAACCAGTATTTTGTTGTTGACGATTTATAGCAAATCTGAGCAAGAAGATATGACAACGGAGCAAAT
TCAAACGATTTTAGAGGAGCTGTATGAATCAGAATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9152.44 Da
• Isoelectric Point: 4.2346

>AT28520 WP_015149782.1 NC_019693:4521970-4522215 [Oscillatoria acuminata PCC 6304]
MKAVEVMGKVDDKGQLLLDEPLDIKSESRVKVILLISDEDDLDPDDTPAEEIKASLIRALQEVKAGKTRPISELWERIEH
E

Nucleotide

• Length: 246 bp

>AT28520 NC_019693:4521970-4522215 [Oscillatoria acuminata PCC 6304]
ATGAAAGCAGTTGAAGTCATGGGCAAAGTCGATGATAAGGGCCAACTTTTGTTAGATGAACCTTTAGACATTAAATCCGA
GAGCCGAGTCAAAGTGATTCTCTTGATATCCGATGAAGATGACTTGGATCCGGATGATACTCCCGCCGAGGAAATTAAAG
CTAGTTTAATCCGAGCTTTGCAAGAAGTCAAAGCAGGGAAAACCAGACCCATTTCTGAACTCTGGGAGAGAATTGAGCAT
GAATAA

Structures

Toxin

• AlphaFold DB: K9TKT8

Antitoxin

• AlphaFold DB: K9TMA9