Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2353763..2354989 Replicon chromosome
Accession NZ_HG938371
Organism Burkholderia cenocepacia H111

Toxin (Protein)


Gene name vapC Uniprot ID A0A364GRG0
Locus tag I35_RS26770 Protein ID WP_006498847.1
Coordinates 2354408..2354989 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I35_RS26765 Protein ID WP_006483170.1
Coordinates 2353763..2354329 (+) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I35_RS26740 2349156..2349791 + 636 WP_006498852.1 cysteine hydrolase -
I35_RS26745 2349817..2350548 - 732 WP_006498851.1 ribonuclease T2 -
I35_RS26750 2350779..2351168 + 390 WP_006498850.1 OsmC family protein -
I35_RS26755 2351247..2351819 - 573 WP_006498849.1 hypothetical protein -
I35_RS26760 2351913..2353316 - 1404 WP_006498848.1 hypothetical protein -
I35_RS26765 2353763..2354329 + 567 WP_006483170.1 helix-turn-helix domain-containing protein Antitoxin
I35_RS26770 2354408..2354989 + 582 WP_006498847.1 HD domain-containing protein Toxin
I35_RS26775 2355045..2355773 + 729 WP_006498846.1 class I SAM-dependent methyltransferase -
I35_RS26780 2356045..2357238 + 1194 WP_043206097.1 efflux RND transporter periplasmic adaptor subunit -
I35_RS26785 2357241..2359274 + 2034 WP_006498844.1 MacB family efflux pump subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21312.88 Da        Isoelectric Point: 4.9572

>T285183 WP_006498847.1 NZ_HG938371:2354408-2354989 [Burkholderia cenocepacia H111]
MNPDTIRARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRAARDEIVALWDEYEAATSPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIREIVDVDTQRRIDAGGQRA

Download         Length: 582 bp

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 20583.56 Da        Isoelectric Point: 10.7753

>AT285183 WP_006483170.1 NZ_HG938371:2353763-2354329 [Burkholderia cenocepacia H111]
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFRVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
STGRMHLVCDLTHRLLASSPARAAEFSRPLSTLLGASLWRYATPEIARMEAALDPLGWYDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAVRLVETLDAH

Download         Length: 567 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364GRG0

Antitoxin

Source ID Structure

References