Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2070369..2071111 Replicon chromosome
Accession NZ_HG938371
Organism Burkholderia cenocepacia H111

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I35_RS25615 Protein ID WP_006496180.1
Coordinates 2070369..2070881 (-) Length 171 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I35_RS25620 Protein ID WP_046338145.1
Coordinates 2070878..2071111 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I35_RS25590 2065912..2066709 + 798 WP_006496182.1 AraC family transcriptional regulator -
I35_RS25595 2066888..2067820 + 933 WP_006496181.1 DMT family transporter -
I35_RS25600 2068024..2068572 + 549 WP_006485834.1 hypothetical protein -
I35_RS25605 2068667..2068801 - 135 WP_006485835.1 entericidin A/B family lipoprotein -
I35_RS25610 2069036..2070331 + 1296 WP_006485851.1 aspartate carbamoyltransferase -
I35_RS25615 2070369..2070881 - 513 WP_006496180.1 type II toxin-antitoxin system VapC family toxin Toxin
I35_RS25620 2070878..2071111 - 234 WP_046338145.1 plasmid stability protein Antitoxin
I35_RS25625 2071413..2073656 + 2244 WP_006496178.1 TonB-dependent siderophore receptor -
I35_RS25630 2073660..2074415 + 756 WP_006496177.1 sel1 repeat family protein -
I35_RS25635 2074412..2075095 + 684 WP_006496176.1 Fe2+-dependent dioxygenase -
I35_RS25640 2075164..2075403 + 240 WP_006496175.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
I35_RS25645 2075616..2075870 + 255 WP_006496174.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 18730.70 Da        Isoelectric Point: 11.3840

>T285182 WP_006496180.1 NZ_HG938371:c2070881-2070369 [Burkholderia cenocepacia H111]
MIPVDTNVMPEPLRREPNAAVIEWLDAQNVETLYLAAIGLAELRFGVAALREGRRRDWLQQSIGQRVLSLFRGRILPFDD
AASRAYASFCARTRAAGNAIAVADGYIAATAEANGSIVATRDVAPFQALGLRIIDPWAVRFAIAGSFGVPKCKTRRAWRR
VLNRTIRLVP

Download         Length: 513 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8290.44 Da        Isoelectric Point: 4.4475

>AT285182 WP_046338145.1 NZ_HG938371:c2071111-2070878 [Burkholderia cenocepacia H111]
VITVRNLPDEVHRALRIGAARHGRSTEAEVRDILEQAVLPGGRLELGTLLAEIGREAGDVDIGVLCDEMPTGPMSFE

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References