Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1949551..1951342 Replicon chromosome
Accession NZ_HG938371
Organism Burkholderia cenocepacia H111

Toxin (Protein)


Gene name doc Uniprot ID A0A364H4T8
Locus tag I35_RS25050 Protein ID WP_006496927.1
Coordinates 1950446..1951342 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A364H4C6
Locus tag I35_RS25045 Protein ID WP_006496928.1
Coordinates 1949551..1950408 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I35_RS25025 1944714..1946204 - 1491 WP_006487205.1 aldehyde dehydrogenase -
I35_RS25030 1946277..1947104 - 828 WP_006496931.1 aspartate dehydrogenase -
I35_RS25035 1947097..1948764 - 1668 WP_006496930.1 thiamine pyrophosphate-binding protein -
I35_RS25040 1948757..1949554 - 798 WP_006496929.1 SDR family oxidoreductase -
I35_RS25045 1949551..1950408 - 858 WP_006496928.1 IclR family transcriptional regulator Antitoxin
I35_RS25050 1950446..1951342 - 897 WP_006496927.1 alpha/beta fold hydrolase Toxin
I35_RS25055 1951361..1951888 - 528 WP_006489904.1 cupin domain-containing protein -
I35_RS25060 1951923..1952693 - 771 WP_006496926.1 SDR family oxidoreductase -
I35_RS25065 1952686..1953756 - 1071 WP_006489909.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
I35_RS25070 1953806..1954117 - 312 WP_006489911.1 hypothetical protein -
I35_RS25075 1954119..1954436 - 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
I35_RS25080 1954881..1955960 + 1080 WP_006489902.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30543.75 Da        Isoelectric Point: 7.7324

>T285181 WP_006496927.1 NZ_HG938371:c1951342-1950446 [Burkholderia cenocepacia H111]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVTPARIAGLLLVSPAGGYGSAPAETR
EARRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAAYSALIDSFCRQCDTQWGLA

Download         Length: 897 bp

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31371.86 Da        Isoelectric Point: 6.5061

>AT285181 WP_006496928.1 NZ_HG938371:c1950408-1949551 [Burkholderia cenocepacia H111]
MSEPLQQNESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGVLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364H4T8

Antitoxin

Source ID Structure
AlphaFold DB A0A364H4C6

References