Detailed information of TA system TA285180

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1688499..1689138
• Replicon: chromosome
• Accession: NZ_HG938371
• Organism: Burkholderia cenocepacia H111

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I35_RS23925
• Protein ID: WP_006481544.1
• Coordinates: 1688499..1688915 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A364H554
• Locus tag: I35_RS23930
• Protein ID: WP_006481537.1
• Coordinates: 1688902..1689138 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I35_RS23900	1683606..1684706	-	1101	WP_006494772.1	nitronate monooxygenase	-
I35_RS23905	1684703..1685623	-	921	WP_006481536.1	enoyl-CoA hydratase	-
I35_RS23910	1685632..1686429	-	798	WP_006481539.1	hypothetical protein	-
I35_RS23915	1686440..1687333	-	894	WP_043204678.1	CoA transferase subunit A	-
I35_RS23920	1687343..1688239	-	897	WP_006494769.1	VOC family protein	-
I35_RS23925	1688499..1688915	-	417	WP_006481544.1	type II toxin-antitoxin system VapC family toxin	Toxin
I35_RS23930	1688902..1689138	-	237	WP_006481537.1	DNA-binding protein	Antitoxin
I35_RS23935	1689631..1690857	+	1227	WP_034202283.1	acyltransferase	-
I35_RS23940	1690868..1691545	-	678	WP_077176171.1	hypothetical protein	-
I35_RS23945	1692194..1692967	-	774	WP_006494765.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15402.64 Da
• Isoelectric Point: 6.8818

>T285180 WP_006481544.1 NZ_HG938371:c1688915-1688499 [Burkholderia cenocepacia H111]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Nucleotide

• Length: 417 bp

>T285180 NZ_HG938371:c1688915-1688499 [Burkholderia cenocepacia H111]
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGAGGGCGTTCTTCAG
GCAGGCCGAAGCGGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGCTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCTTGGCTCACGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCGTTGATCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.78 Da
• Isoelectric Point: 5.0916

>AT285180 WP_006481537.1 NZ_HG938371:c1689138-1688902 [Burkholderia cenocepacia H111]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT285180 NZ_HG938371:c1689138-1688902 [Burkholderia cenocepacia H111]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAAAGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGTGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A364H554