Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1169070..1169716 Replicon chromosome
Accession NZ_HG938371
Organism Burkholderia cenocepacia H111

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I35_RS21680 Protein ID WP_006495106.1
Coordinates 1169309..1169716 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B4EGU8
Locus tag I35_RS21675 Protein ID WP_006491146.1
Coordinates 1169070..1169312 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I35_RS21660 1165064..1166470 + 1407 WP_006491136.1 aspartate ammonia-lyase -
I35_RS21665 1166548..1168053 + 1506 WP_006495108.1 amino acid permease -
I35_RS21670 1168128..1168811 - 684 WP_006495107.1 phospholipase -
I35_RS21675 1169070..1169312 + 243 WP_006491146.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I35_RS21680 1169309..1169716 + 408 WP_006495106.1 type II toxin-antitoxin system VapC family toxin Toxin
I35_RS21685 1170118..1172493 + 2376 WP_006495105.1 MCP four helix bundle domain-containing protein -
I35_RS21690 1172516..1173244 + 729 WP_043204802.1 chemotaxis protein -
I35_RS21695 1173241..1173822 + 582 WP_006495103.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14875.95 Da        Isoelectric Point: 6.1295

>T285179 WP_006495106.1 NZ_HG938371:1169309-1169716 [Burkholderia cenocepacia H111]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHELYYGAYKSQRAAANVARVDALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARHLVLVTHNVREFERVPRLQFEDWLAEPSAD

Download         Length: 408 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.02 Da        Isoelectric Point: 5.0197

>AT285179 WP_006491146.1 NZ_HG938371:1169070-1169312 [Burkholderia cenocepacia H111]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EGU8

References