Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 85315..85952 Replicon chromosome
Accession NZ_HG938370
Organism Burkholderia cenocepacia H111

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I35_RS00365 Protein ID WP_043205292.1
Coordinates 85551..85952 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A364GPY9
Locus tag I35_RS00360 Protein ID WP_034201144.1
Coordinates 85315..85551 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I35_RS00340 80712..81728 + 1017 WP_006493582.1 helix-turn-helix domain-containing protein -
I35_RS00345 81838..82935 - 1098 WP_006496286.1 ADP-heptose--LPS heptosyltransferase -
I35_RS00350 82932..84635 - 1704 WP_006496285.1 thiamine pyrophosphate-binding protein -
I35_RS00355 84950..85197 + 248 Protein_72 type II toxin-antitoxin system RelE/ParE family toxin -
I35_RS00360 85315..85551 + 237 WP_034201144.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I35_RS00365 85551..85952 + 402 WP_043205292.1 type II toxin-antitoxin system VapC family toxin Toxin
I35_RS00370 86020..87408 - 1389 WP_006485681.1 L-serine ammonia-lyase -
I35_RS00375 87439..88581 - 1143 WP_006496280.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15071.28 Da        Isoelectric Point: 6.2271

>T285176 WP_043205292.1 NZ_HG938370:85551-85952 [Burkholderia cenocepacia H111]
MPRFMLDTNMCIYLMKNQPEQVARRFARCYTGDVVMSAITYAELEYGLTACANPARERRHLAALIEDIPVAPFDAAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Download         Length: 402 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8982.15 Da        Isoelectric Point: 6.4701

>AT285176 WP_034201144.1 NZ_HG938370:85315-85551 [Burkholderia cenocepacia H111]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLAKFAKFGPDFMADGRGDHEQAEREGL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A364GPY9

References