285173

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 281115..281800 Replicon plasmid pHAMBI1141a
Accession NZ_HG938356
Organism Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141

Toxin (Protein)


Gene name vapC Uniprot ID A0A068TGA1
Locus tag RG1141_RS23820 Protein ID WP_040124183.1
Coordinates 281115..281537 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A068TF57
Locus tag RG1141_RS23825 Protein ID WP_040124185.1
Coordinates 281534..281800 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG1141_RS23800 276509..277429 - 921 WP_040124178.1 ABC transporter permease -
RG1141_RS23805 277471..278991 - 1521 WP_040124180.1 ABC transporter substrate-binding protein -
RG1141_RS23810 279203..279988 + 786 WP_040125697.1 IclR family transcriptional regulator -
RG1141_RS23815 280061..280783 + 723 WP_040124182.1 ribonuclease activity regulator RraA -
RG1141_RS23820 281115..281537 - 423 WP_040124183.1 type II toxin-antitoxin system VapC family toxin Toxin
RG1141_RS23825 281534..281800 - 267 WP_040124185.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RG1141_RS23830 281890..282330 - 441 WP_040124186.1 fucose-binding protein -
RG1141_RS23835 282695..283756 + 1062 WP_040124187.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
RG1141_RS23840 283833..285494 + 1662 WP_040124189.1 sugar ABC transporter substrate-binding protein -
RG1141_RS23845 285606..286715 + 1110 WP_040124190.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB / htpB 1..1638739 1638739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-63)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15398.63 Da        Isoelectric Point: 5.2052

>T285173 WP_040124183.1 NZ_HG938356:c281537-281115 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
VKLLIDTNVLSEVTKPHPDARVLEWLGGLDEDRAYISVISIAEIRRGVALMDSGRKRDTLAEWLSHDLPQRFEGRVIPVE
EPVALSWGDLMALAKQSGRGLASMDGLIAATAIAHHLTLATRNTKDFEGFGIDMINPWNG

Download         Length: 423 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9792.13 Da        Isoelectric Point: 8.8061

>AT285173 WP_040124185.1 NZ_HG938356:c281800-281534 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
MRPSAHDDRIWTVAGAKAKLSEVIERAQSAPQTITRNGKPSVVVVSAEEWQRKIARKGSLAEFLMDSPLRGAGLDLDRER
DEPRDLPL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068TGA1

Antitoxin

Source ID Structure
AlphaFold DB A0A068TF57

References