285171

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 107921..108507 Replicon plasmid pHAMBI1141a
Accession NZ_HG938356
Organism Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141

Toxin (Protein)


Gene name hicA Uniprot ID A0A068TFW3
Locus tag RG1141_RS22970 Protein ID WP_040123978.1
Coordinates 108253..108507 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A068THI4
Locus tag RG1141_RS22965 Protein ID WP_040123976.1
Coordinates 107921..108256 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG1141_RS22940 103074..104024 - 951 WP_080719313.1 DUF1403 family protein -
RG1141_RS22945 104257..105786 + 1530 WP_040123968.1 carboxypeptidase -
RG1141_RS22950 105908..106630 + 723 WP_040123970.1 L,D-transpeptidase -
RG1141_RS22955 106737..107291 + 555 WP_040123972.1 recombination regulator RecX -
RG1141_RS22960 107313..107780 - 468 WP_040123974.1 truncated hemoglobin -
RG1141_RS22965 107921..108256 - 336 WP_040123976.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
RG1141_RS22970 108253..108507 - 255 WP_040123978.1 type II toxin-antitoxin system HicA family toxin Toxin
RG1141_RS22975 108595..109800 - 1206 WP_040123979.1 3-oxoadipyl-CoA thiolase -
RG1141_RS22980 109812..110501 - 690 WP_040123981.1 CoA transferase subunit B -
RG1141_RS22985 110498..111220 - 723 WP_040123983.1 3-oxoacid CoA-transferase subunit A -
RG1141_RS22990 111412..112167 + 756 WP_040123984.1 IclR family transcriptional regulator -
RG1141_RS22995 112253..112528 + 276 WP_051900277.1 WGR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB / htpB 1..1638739 1638739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9390.85 Da        Isoelectric Point: 10.6566

>T285171 WP_040123978.1 NZ_HG938356:c108507-108253 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
MKKRHRATLELIYARPASGSIRWVDIEAMFVALGADVTEREGSRIGVVLFGEVRVFHRPHPSPDTDKGAVASIRKWLESH
GVKP

Download         Length: 255 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12192.70 Da        Isoelectric Point: 4.5577

>AT285171 WP_040123976.1 NZ_HG938356:c108256-107921 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
MRNVIEIEGHKAVVSLDPEIGMFRGEFLGLNGGADFYSDSLDGLMSEGQKSLQTFLEICKEKGIEPFRSFSGRFNVRLDP
RTHEAAVIAATANDQSLNEWLAETIATAARS

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068TFW3

Antitoxin

Source ID Structure
AlphaFold DB A0A068THI4

References