Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-Xre |
| Location | 101474..102350 | Replicon | plasmid pHAMBI1141a |
| Accession | NZ_HG938356 | ||
| Organism | Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A068TEN1 |
| Locus tag | RG1141_RS22925 | Protein ID | WP_040123961.1 |
| Coordinates | 101474..101989 (-) | Length | 172 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A068TEV5 |
| Locus tag | RG1141_RS22930 | Protein ID | WP_040123962.1 |
| Coordinates | 101982..102350 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RG1141_RS22900 | 96930..97421 | + | 492 | WP_040123955.1 | MarR family transcriptional regulator | - |
| RG1141_RS22905 | 97535..97876 | + | 342 | WP_040123956.1 | YciI family protein | - |
| RG1141_RS22910 | 97882..99138 | + | 1257 | WP_040123957.1 | DNA-directed RNA polymerase sigma-70 factor | - |
| RG1141_RS22915 | 99178..99579 | - | 402 | WP_040123958.1 | response regulator | - |
| RG1141_RS22920 | 99591..101321 | - | 1731 | WP_051900677.1 | ATPase | - |
| RG1141_RS22925 | 101474..101989 | - | 516 | WP_040123961.1 | RES domain-containing protein | Toxin |
| RG1141_RS22930 | 101982..102350 | - | 369 | WP_040123962.1 | DUF2384 domain-containing protein | Antitoxin |
| RG1141_RS22935 | 102427..103071 | - | 645 | WP_040123964.1 | SMC-Scp complex subunit ScpB | - |
| RG1141_RS22940 | 103074..104024 | - | 951 | WP_080719313.1 | DUF1403 family protein | - |
| RG1141_RS22945 | 104257..105786 | + | 1530 | WP_040123968.1 | carboxypeptidase | - |
| RG1141_RS22950 | 105908..106630 | + | 723 | WP_040123970.1 | L,D-transpeptidase | - |
| RG1141_RS22955 | 106737..107291 | + | 555 | WP_040123972.1 | recombination regulator RecX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | htpB / htpB | 1..1638739 | 1638739 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 18707.18 Da Isoelectric Point: 6.0879
>T285170 WP_040123961.1 NZ_HG938356:c101989-101474 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
MPELAPESGILWRAYVPRWAHAPLSGDGAARFGGRWNPVGAATIYAARELSTAWAEYNQGFVQHPALIAQLRLDGARLAD
LTSPEVLSGLGVDETIHRCEWRADLDAGRIPATHLLAERLLDDGRDGVIYPSFMSPGGTCVALWRWNGKDQPKLTVTDPD
GRLPKNPASWL
MPELAPESGILWRAYVPRWAHAPLSGDGAARFGGRWNPVGAATIYAARELSTAWAEYNQGFVQHPALIAQLRLDGARLAD
LTSPEVLSGLGVDETIHRCEWRADLDAGRIPATHLLAERLLDDGRDGVIYPSFMSPGGTCVALWRWNGKDQPKLTVTDPD
GRLPKNPASWL
Download Length: 516 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 12980.01 Da Isoelectric Point: 9.9124
>AT285170 WP_040123962.1 NZ_HG938356:c102350-101982 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
MAHAFEIGAAAFREQQSALLSARRVSDLLGLTQAELAKLIGVARNTLTAKSGARKVDLALSPVVRILAMASEMAGDENRA
AIWFKHQPIPGWAGKTAYDLVGEGKADKVLAYLEAVRSGVYA
MAHAFEIGAAAFREQQSALLSARRVSDLLGLTQAELAKLIGVARNTLTAKSGARKVDLALSPVVRILAMASEMAGDENRA
AIWFKHQPIPGWAGKTAYDLVGEGKADKVLAYLEAVRSGVYA
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A068TEN1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A068TEV5 |